Hepatoma-derived growth factor is associated with reduced sensitivity to irradiation in esophageal cancer

A. Matsuyama, H. Inoue, K. Shibuta, Y. Tanaka, G. F. Barnard, K. Sugimachi, Masaki Mori

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Radiotherapy is a useful component of treatment for esophageal cancer. Identification of the genes that are differentially expressed between radiosensitive and radioresistant cancer cells is important for predicting clinical effectiveness of radiotherapy. We established human esophageal cancer cell lines resistant to X-ray. Using differential display, we obtained one gene that was expressed in radiosensitive cells but was rarely expressed in radioresistant cells, and that gene was identical with hepatoma-derived growth factor (HDGF), an acidic polypeptide with mitogenic activity for fibroblasts. The semiquantitative reverse transcription-PCR assay confirmed that HDGF mRNA expression was reduced in established radioresistant cells, and its reduction was associated with reduced sensitivity to irradiation. Radiotherapy was more effective in clinical cases with high HDGF mRNA expression compared with cases with low expression (P <0.05). The findings demonstrate that HDGF may play an important role in radiosensitivity, and it could be a novel marker predicting effectiveness of radiotherapy in clinical cases.

元の言語英語
ページ(範囲)5714-5717
ページ数4
ジャーナルCancer Research
61
発行部数15
出版物ステータス出版済み - 8 1 2001

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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    Matsuyama, A., Inoue, H., Shibuta, K., Tanaka, Y., Barnard, G. F., Sugimachi, K., & Mori, M. (2001). Hepatoma-derived growth factor is associated with reduced sensitivity to irradiation in esophageal cancer. Cancer Research, 61(15), 5714-5717.