Hesperidin potentiates ghrelin signaling

Hajime Suzuki, Akihiro Asakawa, Namiko Kawamura, Takakazu Yagi, Akio Inui

研究成果: ジャーナルへの寄稿学術誌査読

10 被引用数 (Scopus)

抄録

Hesperidin, a flavanone glycoside consisting of the flavone hesperitin bound to the disaccharide rutinose, is found in highly nutritious foods, such as oranges, tangelos, tangerines, grapefruits, and other citrus fruits. Exogenous hesperidin has been shown to influence a wide variety of biological functions, including induction of apoptosis and suppression of proliferation in human cancer cells; inhibition of tumor development in various tissues; and expression of antibacterial, antiviral, and antifungal activities. Previous in vivo studies have revealed that hesperidin may play a role in ghrelin secretion from the stomach through antagonism of the serotonin receptors. Because ghrelin appears to be involved in the pathophysiological mechanisms of several human disorders, hesperidin could be a promising target for the treatment of various diseases. This review addresses studies focused on the orexigenic and prokinetic activities of hesperidin in the context of ghrelin secretion. This article also presents some promising patents of hesperidin.

本文言語英語
ページ(範囲)60-63
ページ数4
ジャーナルRecent patents on food, nutrition & agriculture
6
1
DOI
出版ステータス出版済み - 2014
外部発表はい

!!!All Science Journal Classification (ASJC) codes

  • 食品科学
  • 農業および作物学

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