Heterogeneity and 'memory' in stem cell populations

Patrick S. Stumpf, Fumio Arai, Ben D. Macarthur

研究成果: Contribution to journalArticle査読

1 被引用数 (Scopus)

抄録

Modern single cell experiments have revealed unexpected heterogeneity in apparently functionally 'pure' cell populations. However, we are still lacking a conceptual framework to understand this heterogeneity. Here, we propose that cellular memories - changes in the molecular status of a cell in response to a stimulus, that modify the ability of the cell to respond to future stimuli - are an essential ingredient in any such theory. We illustrate this idea by considering a simple age-structured model of stem cell proliferation that takes account of mitotic memories. Using this model we argue that asynchronous mitosis generates heterogeneity that is central to stem cell population function. This model naturally explains why stem cell numbers increase through life, yet regenerative potency simultaneously declines.

本文言語英語
論文番号065013
ジャーナルPhysical Biology
17
6
DOI
出版ステータス出版済み - 11 1 2020
外部発表はい

All Science Journal Classification (ASJC) codes

  • 生物理学
  • 構造生物学
  • 分子生物学
  • 細胞生物学

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