Heterogeneous reorganization of actin filaments in living endothelial cellin response to shear stress

研究成果: Contribution to journalArticle査読

抄録

In this study, we investigated the spatial and temporal reorganization of actin filaments in living endothelial cells in response to shear stress by transfecting a fluorescent protein, Dronpa-Green-labeled actin, which was photoactivated microscopically by UV irradiation, and evaluating the time constants of fluorescence decay after photoactivation. The time constant in the upstream region decreased gradually after 30 min of shear stress and then increased. Particularly, the time constant in the downstream region tended to be higher than in the upstream region, suggesting that actin polymerization was more activated in the downstream region. Our results demonstrated the spatial and temporal heterogeneity of actin reorganization due to shear stress.

本文言語英語
ページ(範囲)18-24
ページ数7
ジャーナルJournal of Biorheology
34
1
DOI
出版ステータス出版済み - 2020

All Science Journal Classification (ASJC) codes

  • 材料科学(全般)
  • 材料力学
  • 機械工学

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