High aromatase activity and overexpression of epidermal growth factor receptor in fibrolamellar hepatocellular carcinoma in a child

Katsumi Muramori, Syouhei Taguchi, Tomoaki Taguchi, Kenichi Kohashi, Keizo Furuya, Kiriko Tokuda, Eiichi Ishii

研究成果: Contribution to journalArticle査読

15 被引用数 (Scopus)

抄録

An 11-year-old boy was admitted with a liver tumor and underwent right trisegmentectomy for a diagnosis of fibrolamellar hepatocellular carcinoma. He had suffered from bilateral gynecomastia for a year, which improved after complete resection of the tumor. The tumor cells had significant aromatase activity (8.03 pmol/g/h) and contained high levels of estradiol (82.1 pg/mL), which contributed to gynecomastia. Furthermore, overexpression of epidermal growth factor receptor was determined in the tumor cells, which suggests that antitumor strategies using epidermal growth factor receptor antagonists may be effective.

本文言語英語
ページ(範囲)e195-e197
ジャーナルJournal of Pediatric Hematology/Oncology
33
5
DOI
出版ステータス出版済み - 7 2011

All Science Journal Classification (ASJC) codes

  • 小児科学、周産期医学および子どもの健康
  • 血液学
  • 腫瘍学

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