High b value diffusion-weighted imaging is more sensitive to white matter degeneration in Alzheimer's disease

Takashi Yoshiura, Futoshi Mihara, Atsuo Tanaka, Koji Ogomori, Yasumasa Ohyagi, Takayuki Taniwaki, Takeshi Yamada, Takao Yamasaki, Atsushi Ichimiya, Naoko Kinukawa, Yasuo Kuwabara, Hiroshi Honda

    研究成果: Contribution to journalArticle査読

    58 被引用数 (Scopus)

    抄録

    It has been reported that diffusion-weighted imaging (DWI) can detect white matter degeneration in the Alzheimer's disease (AD) brain. We hypothesized that imaging of the slow diffusion component using high b value DWI is more sensitive to AD-related white matter degeneration than is conventional DWI, and therefore we studied the effects of high b value on lesion-to-normal contrast and contrast-to-noise ratio (CNR). Seven AD patients and seven age-matched normal subjects were studied with full-tensor DWI at three different b values (1000, 2000, and 4000 s/mm2) without changing echo time or diffusion time, and the mean diffusivities in the parietal and occipital regions were measured. Statistical analyses revealed that use of higher b values significantly improves both lesion-to-normal contrast and CNR. We concluded that high b value DWI is more sensitive to AD-related white matter degeneration than is conventional DWI.

    本文言語英語
    ページ(範囲)413-419
    ページ数7
    ジャーナルNeuroImage
    20
    1
    DOI
    出版ステータス出版済み - 9 1 2003

    All Science Journal Classification (ASJC) codes

    • 神経学
    • 認知神経科学

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