TY - JOUR
T1 - High frequency of bone recurrence as an initial recurrence site after radical surgery in T1N3 gastric cancer
T2 - a propensity score matching analysis
AU - Tsutsumi, Chikanori
AU - Ohuchida, Kenoki
AU - Shindo, Koji
AU - Moriyama, Taiki
AU - Akagawa, Shin
AU - Maeyama, Ryo
AU - Nagai, Shuntaro
AU - Nakata, Kohei
AU - Nabae, Toshinaga
AU - Suehara, Nobuhiro
AU - Nishihara, Kazuyoshi
AU - Uchiyama, Akihiko
AU - Nakano, Toru
AU - Nakamura, Masafumi
N1 - Funding Information:
We thank H. Nikki March, PhD, from Edanz Group (https://en-author-services.edanz.com/ac) for editing the English text of a draft of this manuscript.
Publisher Copyright:
© 2021, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
PY - 2021/11
Y1 - 2021/11
N2 - Purpose: T1 gastric cancer (GC) with seven or more metastatic lymph nodes is extremely rare, and very few clinical studies have been conducted to evaluate the clinicopathological features of their recurrence. Methods: We retrospectively analyzed the outcomes of T1 GC and T2–4 GC patients who had multiple nodal metastases after radical surgery from 2006 to 2020. Propensity score matching was performed to compare the two groups of patients. Results: After propensity score matching, 18 of 22 patients in the T1 group and 36 of 144 patients in the T2–4 group were selected. Recurrence occurred in six patients (33.3%) in the T1 group. In the T1 group, the most common site of initial recurrence was bone (15.0%). The prevalence of bone recurrence was significantly higher in the T1 group than in the T2–4 group (P = 0.02). The median interval time between radical surgery and bone recurrence was 24 months, and the median survival time after bone recurrence was 14 months. Conclusion: Bone recurrence was more frequently identified as an initial recurrence site in T1 GC cases with multiple metastases after radical surgery compared with that in T2–4 GC cases. Careful attention should be paid to postoperative bone recurrence in the long-term postoperative course of these patients.
AB - Purpose: T1 gastric cancer (GC) with seven or more metastatic lymph nodes is extremely rare, and very few clinical studies have been conducted to evaluate the clinicopathological features of their recurrence. Methods: We retrospectively analyzed the outcomes of T1 GC and T2–4 GC patients who had multiple nodal metastases after radical surgery from 2006 to 2020. Propensity score matching was performed to compare the two groups of patients. Results: After propensity score matching, 18 of 22 patients in the T1 group and 36 of 144 patients in the T2–4 group were selected. Recurrence occurred in six patients (33.3%) in the T1 group. In the T1 group, the most common site of initial recurrence was bone (15.0%). The prevalence of bone recurrence was significantly higher in the T1 group than in the T2–4 group (P = 0.02). The median interval time between radical surgery and bone recurrence was 24 months, and the median survival time after bone recurrence was 14 months. Conclusion: Bone recurrence was more frequently identified as an initial recurrence site in T1 GC cases with multiple metastases after radical surgery compared with that in T2–4 GC cases. Careful attention should be paid to postoperative bone recurrence in the long-term postoperative course of these patients.
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U2 - 10.1007/s00423-021-02231-8
DO - 10.1007/s00423-021-02231-8
M3 - Article
C2 - 34117530
AN - SCOPUS:85107540352
VL - 406
SP - 2305
EP - 2313
JO - Langenbeck's Archives of Surgery
JF - Langenbeck's Archives of Surgery
SN - 1435-2443
IS - 7
ER -