High incidence of complications from enoxaparin treatment after arthroplasty

Andrew S. Neviaser, Charles Chang, Leonard Lyman Stephen, Alejandro Gonzales Della Valle, Steven B. Haas

研究成果: ジャーナルへの寄稿記事

22 引用 (Scopus)

抄録

Pulmonary embolism (PE) complicates 1% to 10% of total joint arthroplasties and generally requires immediate anticoagulation. Low-molecular-weight heparins have supplanted unfractionated heparin as the treatment of choice for PE and hold a 1A recommendation from the American College of Chest Physicians for this indication. However, the complications of enoxaparin treatment begun in close proximity to arthroplasty surgery are not well described. We examined the records of 135 patients who underwent total joint arthroplasty, experienced an in-hospital PE, and received treatment with enoxaparin at therapeutic doses (1 mg/kg body weight). The type and frequency of complications were determined and classified as major or minor. Twenty-seven percent of patients experienced minor complications and 10% experienced major complications. The incidence of major bleeding was substantially higher than rates reported for nonsurgical patients. The overall complication rate of enoxaparin treatment is similar to the rate of complications reported for unfractionated heparin treatment in this setting, but the complications are less severe. Level of Evidence: Level IV, therapeutic study. See the Guidelines for Authors for a complete description of levels of evidence.

元の言語英語
ページ(範囲)115-119
ページ数5
ジャーナルClinical orthopaedics and related research
468
発行部数1
DOI
出版物ステータス出版済み - 1 1 2010
外部発表Yes

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Enoxaparin
Arthroplasty
Incidence
Pulmonary Embolism
Therapeutics
Heparin
Joints
Low Molecular Weight Heparin
Body Weight
Guidelines
Hemorrhage

All Science Journal Classification (ASJC) codes

  • Orthopedics and Sports Medicine

これを引用

High incidence of complications from enoxaparin treatment after arthroplasty. / Neviaser, Andrew S.; Chang, Charles; Lyman Stephen, Leonard; Gonzales Della Valle, Alejandro; Haas, Steven B.

:: Clinical orthopaedics and related research, 巻 468, 番号 1, 01.01.2010, p. 115-119.

研究成果: ジャーナルへの寄稿記事

Neviaser, Andrew S. ; Chang, Charles ; Lyman Stephen, Leonard ; Gonzales Della Valle, Alejandro ; Haas, Steven B. / High incidence of complications from enoxaparin treatment after arthroplasty. :: Clinical orthopaedics and related research. 2010 ; 巻 468, 番号 1. pp. 115-119.
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