High-level activities of daily living and disease-specific mortality during a 12-year follow-up of an octogenarian population

Yutaka Takata, Toshihiro Ansai, Inho Soh, Shuji Awano, Ikuo Nakamichi, Sumio Akifusa, Kenichi Goto, Akihiro Yoshida, Hiroki Fujii, Ritsuko Fujisawa, Kazuo Sonoki

研究成果: ジャーナルへの寄稿記事

10 引用 (Scopus)

抄録

Background: Little is known about the relationship between disease-specific mortality and high-level activities of daily living in the elderly. We examined whether mortality is associated with high-level activities of daily living in an octogenarian population. Methods: We conducted a population-based cross-sectional and prospective cohort study in 693 older persons aged 80 years and living in Japan's Fukuoka Prefecture. We then evaluated the association between 12-year disease-specific mortality and high-level functional capacity as measured by the Tokyo Metropolitan Institute of Gerontology Index of Competence, which is a standardized multidimensional 13-item instrument; items 1 through 5 are classified as instrumental self-maintenance activity, items 6 through 9 as intellectual activity, items 10 through 13 as social roles activity, and all 13 items together yield total functional capacity. Results: By the 12-year follow-up of the 693 participants, 413 had died, 242 survived, and 38 were unable to be located. Of the 413 who died, 105 died of cardiovascular disease, 73 of respiratory tract disease, 71 of cancer, and 39 of senility. Of the other 125 deaths, 59 were due to other diseases, and the cause of death for 66 participants is not known. The hazard ratio (HR) for all-cause mortality, adjusted for confounding factors with multivariate Cox analyses, fell by 6% (HR 0.937, 95% confidence interval [CI] 0.899-0.978, P = 0.003) with each one-point increase in participants' scores on the Tokyo Metropolitan Institute of Gerontology Index of total functional capacity. With one-point increases in instrumental self-maintenance activity and in intellectual activity, the HRs for all-cause mortality decreased by 14% (HR 0.856, 95% CI 0.787-0.930, P = 0.000) and 12% (HR 0.884, 95% CI 0.794-0.983, P = 0.023), respectively. Respiratory mortality with HR adjustment fell by 11% (HR 0.887, 95% CI 0.804-0.978, P = 0.016) and 24% (HR 0.760, 95% CI 0.627-0.922, P = 0.005) with one-point increases in the scores of total functional capacity and instrumental self-maintenance activity, respectively. Similarly, mortality due to senility fell by 16% (HR 0.838, 95% CI 0.743-0.946, P = 0.004), 29% (HR 0.707, 95% CI 0.564-0.886, P = 0.003), and 29% (HR 0.710, 95% CI 0.522-0.966, P = 0.029) with one-point increases in the scores of total functional capacity, instrumental self-maintenance activity, and intellectual activity, respectively. Conclusion: These findings suggest that high-level activities of daily living may be an independent predictor of mortality due to all causes, respiratory disease and senility in older persons.

元の言語英語
ページ(範囲)721-728
ページ数8
ジャーナルClinical interventions in aging
8
DOI
出版物ステータス出版済み - 6 17 2013

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Activities of Daily Living
Confidence Intervals
Mortality
Population
Tokyo
Geriatrics
Respiratory Tract Diseases
Social Adjustment
Mental Competency
Cause of Death
Japan
Cohort Studies
Cardiovascular Diseases
Multivariate Analysis
Prospective Studies
Neoplasms

All Science Journal Classification (ASJC) codes

  • Geriatrics and Gerontology

これを引用

High-level activities of daily living and disease-specific mortality during a 12-year follow-up of an octogenarian population. / Takata, Yutaka; Ansai, Toshihiro; Soh, Inho; Awano, Shuji; Nakamichi, Ikuo; Akifusa, Sumio; Goto, Kenichi; Yoshida, Akihiro; Fujii, Hiroki; Fujisawa, Ritsuko; Sonoki, Kazuo.

:: Clinical interventions in aging, 巻 8, 17.06.2013, p. 721-728.

研究成果: ジャーナルへの寄稿記事

Takata, Y, Ansai, T, Soh, I, Awano, S, Nakamichi, I, Akifusa, S, Goto, K, Yoshida, A, Fujii, H, Fujisawa, R & Sonoki, K 2013, 'High-level activities of daily living and disease-specific mortality during a 12-year follow-up of an octogenarian population', Clinical interventions in aging, 巻. 8, pp. 721-728. https://doi.org/10.2147/CIA.S43480
Takata, Yutaka ; Ansai, Toshihiro ; Soh, Inho ; Awano, Shuji ; Nakamichi, Ikuo ; Akifusa, Sumio ; Goto, Kenichi ; Yoshida, Akihiro ; Fujii, Hiroki ; Fujisawa, Ritsuko ; Sonoki, Kazuo. / High-level activities of daily living and disease-specific mortality during a 12-year follow-up of an octogenarian population. :: Clinical interventions in aging. 2013 ; 巻 8. pp. 721-728.
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abstract = "Background: Little is known about the relationship between disease-specific mortality and high-level activities of daily living in the elderly. We examined whether mortality is associated with high-level activities of daily living in an octogenarian population. Methods: We conducted a population-based cross-sectional and prospective cohort study in 693 older persons aged 80 years and living in Japan's Fukuoka Prefecture. We then evaluated the association between 12-year disease-specific mortality and high-level functional capacity as measured by the Tokyo Metropolitan Institute of Gerontology Index of Competence, which is a standardized multidimensional 13-item instrument; items 1 through 5 are classified as instrumental self-maintenance activity, items 6 through 9 as intellectual activity, items 10 through 13 as social roles activity, and all 13 items together yield total functional capacity. Results: By the 12-year follow-up of the 693 participants, 413 had died, 242 survived, and 38 were unable to be located. Of the 413 who died, 105 died of cardiovascular disease, 73 of respiratory tract disease, 71 of cancer, and 39 of senility. Of the other 125 deaths, 59 were due to other diseases, and the cause of death for 66 participants is not known. The hazard ratio (HR) for all-cause mortality, adjusted for confounding factors with multivariate Cox analyses, fell by 6{\%} (HR 0.937, 95{\%} confidence interval [CI] 0.899-0.978, P = 0.003) with each one-point increase in participants' scores on the Tokyo Metropolitan Institute of Gerontology Index of total functional capacity. With one-point increases in instrumental self-maintenance activity and in intellectual activity, the HRs for all-cause mortality decreased by 14{\%} (HR 0.856, 95{\%} CI 0.787-0.930, P = 0.000) and 12{\%} (HR 0.884, 95{\%} CI 0.794-0.983, P = 0.023), respectively. Respiratory mortality with HR adjustment fell by 11{\%} (HR 0.887, 95{\%} CI 0.804-0.978, P = 0.016) and 24{\%} (HR 0.760, 95{\%} CI 0.627-0.922, P = 0.005) with one-point increases in the scores of total functional capacity and instrumental self-maintenance activity, respectively. Similarly, mortality due to senility fell by 16{\%} (HR 0.838, 95{\%} CI 0.743-0.946, P = 0.004), 29{\%} (HR 0.707, 95{\%} CI 0.564-0.886, P = 0.003), and 29{\%} (HR 0.710, 95{\%} CI 0.522-0.966, P = 0.029) with one-point increases in the scores of total functional capacity, instrumental self-maintenance activity, and intellectual activity, respectively. Conclusion: These findings suggest that high-level activities of daily living may be an independent predictor of mortality due to all causes, respiratory disease and senility in older persons.",
author = "Yutaka Takata and Toshihiro Ansai and Inho Soh and Shuji Awano and Ikuo Nakamichi and Sumio Akifusa and Kenichi Goto and Akihiro Yoshida and Hiroki Fujii and Ritsuko Fujisawa and Kazuo Sonoki",
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TY - JOUR

T1 - High-level activities of daily living and disease-specific mortality during a 12-year follow-up of an octogenarian population

AU - Takata, Yutaka

AU - Ansai, Toshihiro

AU - Soh, Inho

AU - Awano, Shuji

AU - Nakamichi, Ikuo

AU - Akifusa, Sumio

AU - Goto, Kenichi

AU - Yoshida, Akihiro

AU - Fujii, Hiroki

AU - Fujisawa, Ritsuko

AU - Sonoki, Kazuo

PY - 2013/6/17

Y1 - 2013/6/17

N2 - Background: Little is known about the relationship between disease-specific mortality and high-level activities of daily living in the elderly. We examined whether mortality is associated with high-level activities of daily living in an octogenarian population. Methods: We conducted a population-based cross-sectional and prospective cohort study in 693 older persons aged 80 years and living in Japan's Fukuoka Prefecture. We then evaluated the association between 12-year disease-specific mortality and high-level functional capacity as measured by the Tokyo Metropolitan Institute of Gerontology Index of Competence, which is a standardized multidimensional 13-item instrument; items 1 through 5 are classified as instrumental self-maintenance activity, items 6 through 9 as intellectual activity, items 10 through 13 as social roles activity, and all 13 items together yield total functional capacity. Results: By the 12-year follow-up of the 693 participants, 413 had died, 242 survived, and 38 were unable to be located. Of the 413 who died, 105 died of cardiovascular disease, 73 of respiratory tract disease, 71 of cancer, and 39 of senility. Of the other 125 deaths, 59 were due to other diseases, and the cause of death for 66 participants is not known. The hazard ratio (HR) for all-cause mortality, adjusted for confounding factors with multivariate Cox analyses, fell by 6% (HR 0.937, 95% confidence interval [CI] 0.899-0.978, P = 0.003) with each one-point increase in participants' scores on the Tokyo Metropolitan Institute of Gerontology Index of total functional capacity. With one-point increases in instrumental self-maintenance activity and in intellectual activity, the HRs for all-cause mortality decreased by 14% (HR 0.856, 95% CI 0.787-0.930, P = 0.000) and 12% (HR 0.884, 95% CI 0.794-0.983, P = 0.023), respectively. Respiratory mortality with HR adjustment fell by 11% (HR 0.887, 95% CI 0.804-0.978, P = 0.016) and 24% (HR 0.760, 95% CI 0.627-0.922, P = 0.005) with one-point increases in the scores of total functional capacity and instrumental self-maintenance activity, respectively. Similarly, mortality due to senility fell by 16% (HR 0.838, 95% CI 0.743-0.946, P = 0.004), 29% (HR 0.707, 95% CI 0.564-0.886, P = 0.003), and 29% (HR 0.710, 95% CI 0.522-0.966, P = 0.029) with one-point increases in the scores of total functional capacity, instrumental self-maintenance activity, and intellectual activity, respectively. Conclusion: These findings suggest that high-level activities of daily living may be an independent predictor of mortality due to all causes, respiratory disease and senility in older persons.

AB - Background: Little is known about the relationship between disease-specific mortality and high-level activities of daily living in the elderly. We examined whether mortality is associated with high-level activities of daily living in an octogenarian population. Methods: We conducted a population-based cross-sectional and prospective cohort study in 693 older persons aged 80 years and living in Japan's Fukuoka Prefecture. We then evaluated the association between 12-year disease-specific mortality and high-level functional capacity as measured by the Tokyo Metropolitan Institute of Gerontology Index of Competence, which is a standardized multidimensional 13-item instrument; items 1 through 5 are classified as instrumental self-maintenance activity, items 6 through 9 as intellectual activity, items 10 through 13 as social roles activity, and all 13 items together yield total functional capacity. Results: By the 12-year follow-up of the 693 participants, 413 had died, 242 survived, and 38 were unable to be located. Of the 413 who died, 105 died of cardiovascular disease, 73 of respiratory tract disease, 71 of cancer, and 39 of senility. Of the other 125 deaths, 59 were due to other diseases, and the cause of death for 66 participants is not known. The hazard ratio (HR) for all-cause mortality, adjusted for confounding factors with multivariate Cox analyses, fell by 6% (HR 0.937, 95% confidence interval [CI] 0.899-0.978, P = 0.003) with each one-point increase in participants' scores on the Tokyo Metropolitan Institute of Gerontology Index of total functional capacity. With one-point increases in instrumental self-maintenance activity and in intellectual activity, the HRs for all-cause mortality decreased by 14% (HR 0.856, 95% CI 0.787-0.930, P = 0.000) and 12% (HR 0.884, 95% CI 0.794-0.983, P = 0.023), respectively. Respiratory mortality with HR adjustment fell by 11% (HR 0.887, 95% CI 0.804-0.978, P = 0.016) and 24% (HR 0.760, 95% CI 0.627-0.922, P = 0.005) with one-point increases in the scores of total functional capacity and instrumental self-maintenance activity, respectively. Similarly, mortality due to senility fell by 16% (HR 0.838, 95% CI 0.743-0.946, P = 0.004), 29% (HR 0.707, 95% CI 0.564-0.886, P = 0.003), and 29% (HR 0.710, 95% CI 0.522-0.966, P = 0.029) with one-point increases in the scores of total functional capacity, instrumental self-maintenance activity, and intellectual activity, respectively. Conclusion: These findings suggest that high-level activities of daily living may be an independent predictor of mortality due to all causes, respiratory disease and senility in older persons.

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