High-resolution probing of cellular force transmission

Daisuke Mizuno, Rommel Bacabac, Catherine Tardin, David Head, Christoph F. Schmidt

研究成果: Contribution to journalArticle査読

71 被引用数 (Scopus)

抄録

Cells actively probe mechanical properties of their environment by exerting internally generated forces. The response they encounter profoundly affects their behavior. Here we measure in a simple geometry the forces a cell exerts suspended by two optical traps. Our assay quantifies both the overall force and the fraction of that force transmitted to the environment. Mimicking environments of varying stiffness by adjusting the strength of the traps, we found that the force transmission is highly dependent on external compliance. This suggests a calibration mechanism for cellular mechanosensing.

本文言語英語
論文番号168102
ジャーナルPhysical review letters
102
16
DOI
出版ステータス出版済み - 4 21 2009

All Science Journal Classification (ASJC) codes

  • 物理学および天文学(全般)

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