High throughput mechanical characterization of oocyte using robot integrated microfluidic chip

Shinya Sakuma, Bilal Turan, Fumihito Arai

研究成果: Chapter in Book/Report/Conference proceedingConference contribution

11 被引用数 (Scopus)

抄録

This paper presents a novel measurement system of cellular mechanical properties based on a robot integrated microfluidic chip. In order to achieve the high throughput measurement of cellular mechacal properties, we proposed the robot integrated microfluidic chip (robochip), taking advantages of both of micromechanical manipulator and Lab-on-a-Chip devices. The robochip contained a pair of a magnetically driven on-chip robotic probe and a force sensor. The characterization system based on the robochip performed by the visual feedback control, and the continuous cell measurement was demonstrated. The throughput of our system was 15 to 20 seconds per one oocyte. Moreover, the measurement of the viscoelastic properties were demonstrated as a quality evaluation of oocyte. Experimental results shows that the oocyte has the viscoelastic properties among the same culture condition, and it is important to analyze the mechanical properties of oocyte for the evaluation of the quality. From these results, we concluded that the high through put cellular mechanical characterization was achieved, and our robochip approach was a promising technique for a cellular characterization because the chip part was disposable.

本文言語英語
ホスト出版物のタイトルIROS 2013
ホスト出版物のサブタイトルNew Horizon, Conference Digest - 2013 IEEE/RSJ International Conference on Intelligent Robots and Systems
ページ2047-2052
ページ数6
DOI
出版ステータス出版済み - 2013
外部発表はい
イベント2013 26th IEEE/RSJ International Conference on Intelligent Robots and Systems: New Horizon, IROS 2013 - Tokyo, 日本
継続期間: 11 3 201311 8 2013

出版物シリーズ

名前IEEE International Conference on Intelligent Robots and Systems
ISSN(印刷版)2153-0858
ISSN(電子版)2153-0866

その他

その他2013 26th IEEE/RSJ International Conference on Intelligent Robots and Systems: New Horizon, IROS 2013
国/地域日本
CityTokyo
Period11/3/1311/8/13

All Science Journal Classification (ASJC) codes

  • 制御およびシステム工学
  • ソフトウェア
  • コンピュータ ビジョンおよびパターン認識
  • コンピュータ サイエンスの応用

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