Highlighting interleukin-36 signalling in plaque psoriasis and pustular psoriasis

Kazuhisa Furue, Kazuhiko Yamamura, Gaku Tsuji, Chikage Mitoma, Hiroshi Uchi, Takeshi Nakahara, Makiko Kido-Nakahara, Takafumi Kadono, Masutaka Furue

研究成果: ジャーナルへの寄稿評論記事

17 引用 (Scopus)

抄録

Plaque psoriasis and pustular psoriasis are overlapping, but distinct, disorders. The therapeutic response to biologics supports the pivotal role of the tumour necrosis alpha (TNF-α)/ interleukin (IL)-23/IL-17/IL-22 axis in the pathogenesis of these disorders. Recently, functional activation of the IL-36 receptor (IL-36R) was discovered to be another driving force in the pathogenesis of psoriasis. This was first highlighted by the discovery that a loss-of-function mutation of the IL-36R antagonist (IL-36Ra) causes pustular psoriasis. Although the TNF-α/IL-23/IL-17/IL-22 axis and the functional activation of IL-36R are fundamentally involved in plaque psoriasis and pustular psoriasis, respectively, the 2 pathways are closely related and mutually reinforced, resulting in full-blown clinical manifestations. This review summarizes current topics on how IL-36 agonists (IL-36α, IL-36β, IL-36γ) signal IL-36R, the pathological expression of IL-36 agonists and IL-36Ra in plaque and pustular psoriatic lesions, and the cross-talk between the TNF-α/IL-23/IL-17/ IL-22 axis and the functional activation of IL-36R in the epidermal milieu.

元の言語英語
ページ(範囲)5-13
ページ数9
ジャーナルActa Dermato-Venereologica
98
発行部数1
DOI
出版物ステータス出版済み - 1 1 2018

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Interleukins
Psoriasis
Interleukin-23
Interleukin-17
Interleukin Receptors
Biological Products
Necrosis
Mutation

All Science Journal Classification (ASJC) codes

  • Dermatology

これを引用

Highlighting interleukin-36 signalling in plaque psoriasis and pustular psoriasis. / Furue, Kazuhisa; Yamamura, Kazuhiko; Tsuji, Gaku; Mitoma, Chikage; Uchi, Hiroshi; Nakahara, Takeshi; Kido-Nakahara, Makiko; Kadono, Takafumi; Furue, Masutaka.

:: Acta Dermato-Venereologica, 巻 98, 番号 1, 01.01.2018, p. 5-13.

研究成果: ジャーナルへの寄稿評論記事

Furue, Kazuhisa ; Yamamura, Kazuhiko ; Tsuji, Gaku ; Mitoma, Chikage ; Uchi, Hiroshi ; Nakahara, Takeshi ; Kido-Nakahara, Makiko ; Kadono, Takafumi ; Furue, Masutaka. / Highlighting interleukin-36 signalling in plaque psoriasis and pustular psoriasis. :: Acta Dermato-Venereologica. 2018 ; 巻 98, 番号 1. pp. 5-13.
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