Highly diastereoselective aziridination of α,β-unsaturated amides using diaziridine

Hiroyuki Ishihara, Yoshio N. Ito, Tsutomu Katsuki

研究成果: ジャーナルへの寄稿記事

13 引用 (Scopus)

抜粋

Racemic 3-cyclohexyl-1-methyldiaziridine was found to react with α,β-unsaturated amides in basic conditions, giving N-unprotected trans-aziridines, while 3,3-pentamethylenediaziridine had been reported to afford cis-aziridines in high diastereoselectivity. The trans-selectivity was partially dependent on the stereochemistry of the substrate. The stereochemistries of these reactions were reasonably explained by the conformational analysis of the intermediary enolates.

元の言語英語
ページ(範囲)984-985
ページ数2
ジャーナルChemistry Letters
発行部数10
DOI
出版物ステータス出版済み - 1 1 2001

    フィンガープリント

All Science Journal Classification (ASJC) codes

  • Chemistry(all)

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