Highly efficient and low toxic skin penetrants composed of amino acid ionic liquids

Shin Ya Furukawa, Gaku Hattori, Shinji Sakai, Noriho Kamiya

研究成果: Contribution to journalArticle査読

28 被引用数 (Scopus)

抄録

Herein, we introduce an amino acid ester (AAE) as a potent biocompatible counter ion to formulate ionic liquefied active pharmaceutical ingredients. By equimolar pairing of a non-steroidal anti-inflammatory drug (NSAID) as the anion and the AAE as the cation, the liquid formulation was feasibly obtained. In vitro drug permeation results using pig skin revealed a significant enhancement of the transdermal delivery of the ionic liquefied NSAIDs. The AAE showed much lower cytotoxicity to mouse fibroblast L929 cells when compared with that of conventional counter cations, indicating the significant potential of the AAE in the development of new ionic liquid drug formulations.

本文言語英語
ページ(範囲)87753-87755
ページ数3
ジャーナルRSC Advances
6
90
DOI
出版ステータス出版済み - 2016

All Science Journal Classification (ASJC) codes

  • 化学 (全般)
  • 化学工学(全般)

フィンガープリント

「Highly efficient and low toxic skin penetrants composed of amino acid ionic liquids」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル