Highly enantioselective synthesis of chiral 3-substituted indolines by catalytic asymmetric hydrogenation of indoles

Ryoichi Kuwano, Kohei Kaneda, Takashi Ito, Koji Sato, Takashi Kurokawa, Yoshihiko Ito

研究成果: ジャーナルへの寄稿記事

128 引用 (Scopus)

抄録

N-Tosyl 3-substituted indoles were hydrogenated with high enantioselectivities (95-98% ee) by use of a trans-chelating chiral bisphosphine, (S,S)-(R,R)-PhTRAP ligand. The chiral catalyst, which was generated in situ from [Rh(nbd)2]SbF6, PhTRAP, and Cs 2CO3, is useful for enantioselectively synthesizing a range of diverse optically active indolines possessing a chiral carbon at the 3-position.

元の言語英語
ページ(範囲)2213-2215
ページ数3
ジャーナルOrganic Letters
6
発行部数13
DOI
出版物ステータス出版済み - 6 24 2004

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Indoles
Hydrogenation
Enantioselectivity
indoles
Chelation
hydrogenation
Carbon
Ligands
catalysts
ligands
Catalysts
carbon
synthesis
indoline

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

これを引用

Highly enantioselective synthesis of chiral 3-substituted indolines by catalytic asymmetric hydrogenation of indoles. / Kuwano, Ryoichi; Kaneda, Kohei; Ito, Takashi; Sato, Koji; Kurokawa, Takashi; Ito, Yoshihiko.

:: Organic Letters, 巻 6, 番号 13, 24.06.2004, p. 2213-2215.

研究成果: ジャーナルへの寄稿記事

Kuwano, Ryoichi ; Kaneda, Kohei ; Ito, Takashi ; Sato, Koji ; Kurokawa, Takashi ; Ito, Yoshihiko. / Highly enantioselective synthesis of chiral 3-substituted indolines by catalytic asymmetric hydrogenation of indoles. :: Organic Letters. 2004 ; 巻 6, 番号 13. pp. 2213-2215.
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AU - Sato, Koji

AU - Kurokawa, Takashi

AU - Ito, Yoshihiko

PY - 2004/6/24

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