Highly malleable haem-binding site of the haemoprotein HasA permits stable accommodation of bulky tetraphenylporphycenes

Erika Sakakibara, Yuma Shisaka, Hiroki Onoda, Daiki Koga, Ning Xu, Toshikazu Ono, Yoshio Hisaeda, Hiroshi Sugimoto, Yoshitsugu Shiro, Yoshihito Watanabe, Osami Shoji

研究成果: ジャーナルへの寄稿記事

抄録

Iron(iii)- and cobalt(iii)-9,10,19,20-tetraphenylporphycenes, which possess bulky phenyl groups at the four meso positions of porphycene, were successfully incorporated into the haem acquisition protein HasA secreted by Pseudomonas aeruginosa. Crystal structure analysis revealed that loops surrounding the haem-binding site are highly flexible, remodelling themselves to accommodate bulky metal complexes with significantly different structures from the native haem cofactor.

元の言語英語
ページ(範囲)18697-18702
ページ数6
ジャーナルRSC Advances
9
発行部数32
DOI
出版物ステータス出版済み - 1 1 2019

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Binding sites
Metal complexes
Heme
Cobalt
Crystal structure
Binding Sites
Iron
Proteins
Coordination Complexes

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Chemical Engineering(all)

これを引用

Highly malleable haem-binding site of the haemoprotein HasA permits stable accommodation of bulky tetraphenylporphycenes. / Sakakibara, Erika; Shisaka, Yuma; Onoda, Hiroki; Koga, Daiki; Xu, Ning; Ono, Toshikazu; Hisaeda, Yoshio; Sugimoto, Hiroshi; Shiro, Yoshitsugu; Watanabe, Yoshihito; Shoji, Osami.

:: RSC Advances, 巻 9, 番号 32, 01.01.2019, p. 18697-18702.

研究成果: ジャーナルへの寄稿記事

Sakakibara, E, Shisaka, Y, Onoda, H, Koga, D, Xu, N, Ono, T, Hisaeda, Y, Sugimoto, H, Shiro, Y, Watanabe, Y & Shoji, O 2019, 'Highly malleable haem-binding site of the haemoprotein HasA permits stable accommodation of bulky tetraphenylporphycenes', RSC Advances, 巻. 9, 番号 32, pp. 18697-18702. https://doi.org/10.1039/c9ra02872b
Sakakibara, Erika ; Shisaka, Yuma ; Onoda, Hiroki ; Koga, Daiki ; Xu, Ning ; Ono, Toshikazu ; Hisaeda, Yoshio ; Sugimoto, Hiroshi ; Shiro, Yoshitsugu ; Watanabe, Yoshihito ; Shoji, Osami. / Highly malleable haem-binding site of the haemoprotein HasA permits stable accommodation of bulky tetraphenylporphycenes. :: RSC Advances. 2019 ; 巻 9, 番号 32. pp. 18697-18702.
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AU - Onoda, Hiroki

AU - Koga, Daiki

AU - Xu, Ning

AU - Ono, Toshikazu

AU - Hisaeda, Yoshio

AU - Sugimoto, Hiroshi

AU - Shiro, Yoshitsugu

AU - Watanabe, Yoshihito

AU - Shoji, Osami

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AB - Iron(iii)- and cobalt(iii)-9,10,19,20-tetraphenylporphycenes, which possess bulky phenyl groups at the four meso positions of porphycene, were successfully incorporated into the haem acquisition protein HasA secreted by Pseudomonas aeruginosa. Crystal structure analysis revealed that loops surrounding the haem-binding site are highly flexible, remodelling themselves to accommodate bulky metal complexes with significantly different structures from the native haem cofactor.

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