Histiocytic haemophagocytosis in a patient with Kawasaki disease: Changes in the hypercytokinaemic state

Shouichi Ohga, Akio Ooshima, Junichiro Fukushige, Kohji Ueda

研究成果: Contribution to journalArticle査読

32 被引用数 (Scopus)

抄録

Abstract: A 32-month-old Japanese boy exhibited haemophagocytic syndrome (HPS) during the recurrent course of Kawasaki disease. Despite repeated γ-globulin therapy, he developed cytopenia with marked hepatomegaly and evidence of histiocytic haemophagocytosis in the bone marrow. Serum levels of interferon-γ and tumour necrosis factor, but not of interleukin-1β, increased in parallel with his symptoms. No confirmation was obtained of the association of toxic reactions to the used drugs. No coronary lesions remained as sequelae. Conclusion: Cytopenia in Kawasaki disease could herald HPS, and the hypercytokinaemia involved in the two febrile syndromes might be of distinct nature.

本文言語英語
ページ(範囲)539-541
ページ数3
ジャーナルEuropean Journal of Pediatrics
154
7
DOI
出版ステータス出版済み - 7 1 1995

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health

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