Histological assessments for toxicity and functionalization-dependent biodistribution of carbon nanohorns

Yoshio Tahara, Jin Miyawaki, Minfang Zhang, Mei Yang, Iwao Waga, Sumio Iijima, Hiroshi Irie, Masako Yudasaka

研究成果: ジャーナルへの寄稿学術誌査読

44 被引用数 (Scopus)

抄録

Single-walled carbon nanohorns (SWNHs) intravenously administered to mice did not show severe toxicity during a 26-week test period, which was confirmed by normal gross appearance, normal weight gain and the lack of abnormality in the tissues on histological observations of the mice. SWNH biodistribution was influenced by chemical functionalization. Accumulation of SWNH in the lungs reduced as SWNH hydrophilicity increased; however, the most hydrophilic SWNHs modified with bovine serum albumin (BSA) were most likely to be trapped in the lungs, suggesting that the BSA moiety enhanced macrophage phagocytosis in the lungs. Clearance of some of the hydrophobic SWNHs from the lungs was observed, the mechanism of which is briefly discussed.

本文言語英語
論文番号265106
ジャーナルNanotechnology
22
26
DOI
出版ステータス出版済み - 7月 1 2011
外部発表はい

!!!All Science Journal Classification (ASJC) codes

  • バイオエンジニアリング
  • 化学 (全般)
  • 材料科学(全般)
  • 材料力学
  • 機械工学
  • 電子工学および電気工学

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