Historical changes and between-facility differences in adrenal venous sampling for primary aldosteronism in Japan

JPAS Study Group

研究成果: ジャーナルへの寄稿記事

抄録

Primary aldosteronism (PA) is a common curable cause of hypertension. Adrenal venous sampling (AVS) is recommended for subtype diagnosis but is a difficult procedure. Recently, an increased prevalence of PA was reported, creating a greater demand for treatment of the condition in clinical facilities. The aim of the present study was to identify the historical changes over time and the differences between facilities in the success rate and subtype diagnosis of PA. The database of the PA registry developed by the Japan PA Study (JPAS) was used. A total of 2599 patients with PA who underwent AVS were evaluated. The overall success rate of AVS was 88%. The bilateral subtype was the dominant subtype, comprising 69% of cases. During the period 2004−2011 to 2011−2017, there were significant changes in the total number of AVS procedures (from 562 to 1732), ratio of ACTH administration with AVS (75 to 97%), success rate (79 to 90%), and proportion with bilateral subtype diagnosis (53 to 72%). There were also significant inter-facility differences in the number of AVS procedures (6 to 322), success rate (59 to 97%), and proportion with the bilateral subtype (44 to 86%). The principal enrolled department was Endocrinology (86%), and the ratio of unilateral PA was significantly higher in this department than in others (32% vs. 25%). In conclusion, the number of AVS procedures performed, the success rate, and the proportion with the bilateral subtype increased over time after normalizing the centre difference. Significant differences were observed between the centres.

元の言語英語
ページ(範囲)34-42
ページ数9
ジャーナルJournal of human hypertension
34
発行部数1
DOI
出版物ステータス出版済み - 1 1 2020

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Hyperaldosteronism
Japan
Endocrinology
Adrenocorticotropic Hormone
Registries
Databases
Hypertension

All Science Journal Classification (ASJC) codes

  • Internal Medicine

これを引用

Historical changes and between-facility differences in adrenal venous sampling for primary aldosteronism in Japan. / JPAS Study Group.

:: Journal of human hypertension, 巻 34, 番号 1, 01.01.2020, p. 34-42.

研究成果: ジャーナルへの寄稿記事

@article{445aede685be4925a15e101af468b120,
title = "Historical changes and between-facility differences in adrenal venous sampling for primary aldosteronism in Japan",
abstract = "Primary aldosteronism (PA) is a common curable cause of hypertension. Adrenal venous sampling (AVS) is recommended for subtype diagnosis but is a difficult procedure. Recently, an increased prevalence of PA was reported, creating a greater demand for treatment of the condition in clinical facilities. The aim of the present study was to identify the historical changes over time and the differences between facilities in the success rate and subtype diagnosis of PA. The database of the PA registry developed by the Japan PA Study (JPAS) was used. A total of 2599 patients with PA who underwent AVS were evaluated. The overall success rate of AVS was 88{\%}. The bilateral subtype was the dominant subtype, comprising 69{\%} of cases. During the period 2004−2011 to 2011−2017, there were significant changes in the total number of AVS procedures (from 562 to 1732), ratio of ACTH administration with AVS (75 to 97{\%}), success rate (79 to 90{\%}), and proportion with bilateral subtype diagnosis (53 to 72{\%}). There were also significant inter-facility differences in the number of AVS procedures (6 to 322), success rate (59 to 97{\%}), and proportion with the bilateral subtype (44 to 86{\%}). The principal enrolled department was Endocrinology (86{\%}), and the ratio of unilateral PA was significantly higher in this department than in others (32{\%} vs. 25{\%}). In conclusion, the number of AVS procedures performed, the success rate, and the proportion with the bilateral subtype increased over time after normalizing the centre difference. Significant differences were observed between the centres.",
author = "{JPAS Study Group} and Yuichi Fujii and Yoshiyu Takeda and Isao Kurihara and Hiroshi Itoh and Takuyuki Katabami and Takamasa Ichijo and Norio Wada and Yui Shibayama and Takanobu Yoshimoto and Yoshihiro Ogawa and Junji Kawashima and Masakatsu Sone and Nobuya Inagaki and Katsutoshi Takahashi and Minemori Watanabe and Yuichi Matsuda and Hiroki Kobayashi and Hirotaka Shibata and Kohei Kamemura and Michio Otsuki and Koichi Yamamto and Atsushi Ogo and Toshihiko Yanase and Shintaro Okamura and Shozo Miyauchi and Megumi Fujita and Tomoko Suzuki and Hironobu Umakoshi and Tatsuki Ogasawara and Mika Tsuiki and Mitsuhide Naruse and Masanobu Yamada and Hiromi Rakugi and Takashi Kawamura and Osamu Ogawa and Akiyo Tanabe and Tomonobu Hasegawa and Masanori Abe and Ryuichi Sakamoto and Takuro Shinbo and Tatsuya Kai and Tomikazu Fukuoka and Masanori Murakami and Shigeatsu Hashimoto and Makito Tanabe and Mitsuhiro Kometani and Yuichirou Yoshikawa and Youichi Oono and Hisashi Fukuda and Takashi Yoneda",
year = "2020",
month = "1",
day = "1",
doi = "10.1038/s41371-019-0229-4",
language = "English",
volume = "34",
pages = "34--42",
journal = "Journal of Human Hypertension",
issn = "0950-9240",
publisher = "Nature Publishing Group",
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TY - JOUR

T1 - Historical changes and between-facility differences in adrenal venous sampling for primary aldosteronism in Japan

AU - JPAS Study Group

AU - Fujii, Yuichi

AU - Takeda, Yoshiyu

AU - Kurihara, Isao

AU - Itoh, Hiroshi

AU - Katabami, Takuyuki

AU - Ichijo, Takamasa

AU - Wada, Norio

AU - Shibayama, Yui

AU - Yoshimoto, Takanobu

AU - Ogawa, Yoshihiro

AU - Kawashima, Junji

AU - Sone, Masakatsu

AU - Inagaki, Nobuya

AU - Takahashi, Katsutoshi

AU - Watanabe, Minemori

AU - Matsuda, Yuichi

AU - Kobayashi, Hiroki

AU - Shibata, Hirotaka

AU - Kamemura, Kohei

AU - Otsuki, Michio

AU - Yamamto, Koichi

AU - Ogo, Atsushi

AU - Yanase, Toshihiko

AU - Okamura, Shintaro

AU - Miyauchi, Shozo

AU - Fujita, Megumi

AU - Suzuki, Tomoko

AU - Umakoshi, Hironobu

AU - Ogasawara, Tatsuki

AU - Tsuiki, Mika

AU - Naruse, Mitsuhide

AU - Yamada, Masanobu

AU - Rakugi, Hiromi

AU - Kawamura, Takashi

AU - Ogawa, Osamu

AU - Tanabe, Akiyo

AU - Hasegawa, Tomonobu

AU - Abe, Masanori

AU - Sakamoto, Ryuichi

AU - Shinbo, Takuro

AU - Kai, Tatsuya

AU - Fukuoka, Tomikazu

AU - Murakami, Masanori

AU - Hashimoto, Shigeatsu

AU - Tanabe, Makito

AU - Kometani, Mitsuhiro

AU - Yoshikawa, Yuichirou

AU - Oono, Youichi

AU - Fukuda, Hisashi

AU - Yoneda, Takashi

PY - 2020/1/1

Y1 - 2020/1/1

N2 - Primary aldosteronism (PA) is a common curable cause of hypertension. Adrenal venous sampling (AVS) is recommended for subtype diagnosis but is a difficult procedure. Recently, an increased prevalence of PA was reported, creating a greater demand for treatment of the condition in clinical facilities. The aim of the present study was to identify the historical changes over time and the differences between facilities in the success rate and subtype diagnosis of PA. The database of the PA registry developed by the Japan PA Study (JPAS) was used. A total of 2599 patients with PA who underwent AVS were evaluated. The overall success rate of AVS was 88%. The bilateral subtype was the dominant subtype, comprising 69% of cases. During the period 2004−2011 to 2011−2017, there were significant changes in the total number of AVS procedures (from 562 to 1732), ratio of ACTH administration with AVS (75 to 97%), success rate (79 to 90%), and proportion with bilateral subtype diagnosis (53 to 72%). There were also significant inter-facility differences in the number of AVS procedures (6 to 322), success rate (59 to 97%), and proportion with the bilateral subtype (44 to 86%). The principal enrolled department was Endocrinology (86%), and the ratio of unilateral PA was significantly higher in this department than in others (32% vs. 25%). In conclusion, the number of AVS procedures performed, the success rate, and the proportion with the bilateral subtype increased over time after normalizing the centre difference. Significant differences were observed between the centres.

AB - Primary aldosteronism (PA) is a common curable cause of hypertension. Adrenal venous sampling (AVS) is recommended for subtype diagnosis but is a difficult procedure. Recently, an increased prevalence of PA was reported, creating a greater demand for treatment of the condition in clinical facilities. The aim of the present study was to identify the historical changes over time and the differences between facilities in the success rate and subtype diagnosis of PA. The database of the PA registry developed by the Japan PA Study (JPAS) was used. A total of 2599 patients with PA who underwent AVS were evaluated. The overall success rate of AVS was 88%. The bilateral subtype was the dominant subtype, comprising 69% of cases. During the period 2004−2011 to 2011−2017, there were significant changes in the total number of AVS procedures (from 562 to 1732), ratio of ACTH administration with AVS (75 to 97%), success rate (79 to 90%), and proportion with bilateral subtype diagnosis (53 to 72%). There were also significant inter-facility differences in the number of AVS procedures (6 to 322), success rate (59 to 97%), and proportion with the bilateral subtype (44 to 86%). The principal enrolled department was Endocrinology (86%), and the ratio of unilateral PA was significantly higher in this department than in others (32% vs. 25%). In conclusion, the number of AVS procedures performed, the success rate, and the proportion with the bilateral subtype increased over time after normalizing the centre difference. Significant differences were observed between the centres.

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U2 - 10.1038/s41371-019-0229-4

DO - 10.1038/s41371-019-0229-4

M3 - Article

C2 - 31462725

AN - SCOPUS:85071846527

VL - 34

SP - 34

EP - 42

JO - Journal of Human Hypertension

JF - Journal of Human Hypertension

SN - 0950-9240

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