HLA-A2, HLA-B44 and HLA-DR15 are associated with lower risk of BK viremia

Kosuke Masutani, Toshiharu Ninomiya, Parmjeet Randhawa

研究成果: ジャーナルへの寄稿記事

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Background. Human leucocyte antigens (HLAs) modulate immunity to polyomavirus BK (BKV). Identification of HLAs that alter the course of infection will facilitate risk stratification, and customization of pre-emptive intervention strategies. Methods. We performed a retrospective cohort study with 998 kidney transplant patients with BKV infection status confirmed by polymerase chain reaction (PCR). Clinical parameters and donor-recipient matching for specific HLAs were examined in relation to occurrence of viremia. An emphasis was placed on donor-recipient matching rather than the actual frequency of specific HLA-alleles, since a successful immune response requires sharing of HLAs between a virusinfected target cell and the anti-viral effector cell. Results. Using multivariate statistics, low risk of BK viremia was associated with matching of HLA-A2 [hazard ratio (HR) 0.51, 95% confidence interval (CI) 0.28-0.85], HLA-B44 (HR 0.31, 95% CI 0.076-0.85) and HLA-DR15 (HR 0.35, 95% CI 0.084-0.93) (P < 0.05), whereas high risk of viremia was associated with male gender (HR 2.38, 95% CI 1.46-4.09, P < 0.001). Conclusions. HLAs that associated with a lower predisposition to the development of BK viremia have been identified. Evaluation of donor-recipient mismatching for these HLAs could potentially be used to (i) fine tune virus screening strategies for BKV in individual patients and (ii) facilitate discovery of major histocompatibility complex (MHC) class I and II binding peptides that can elicit clinically meaningful BKVspecific immunity.

元の言語英語
ページ(範囲)3119-3126
ページ数8
ジャーナルNephrology Dialysis Transplantation
28
発行部数12
DOI
出版物ステータス出版済み - 12 1 2013

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All Science Journal Classification (ASJC) codes

  • Nephrology
  • Transplantation

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