TY - JOUR
T1 - HLA and Graves’ Disease or Diabetes Mellitus in Japan
AU - Sasazuki, T.
AU - Kohno, Y.
AU - Iwamoto, I.
AU - Kosaka, K.
AU - Okimoto, K.
AU - Maruyama, H.
AU - Ishiba, S.
AU - Konishi, J.
AU - Takeda, Y.
AU - Naito, S.
PY - 1978/3/16
Y1 - 1978/3/16
N2 - To the Editor: A significant increase in the incidence of HLA-B8 and Dw3 has been reported in white patients with several autoimmune diseases, including juvenile-onset diabetes mellitus1 and Graves’ disease.23 Two possibilities to explain this phenomenon have been proposed.4 In the first, these two different organ-specific autoimmune diseases might be associated with the same allele of the same gene, and there might be a common initiating pathogenic event in these diseases; secondly, each of these diseases might be associated with a particular allele of different genes, both of which are in linkage disequilibrium with HLA-B8 and HLA-Dw3. Sasazuki et al.
AB - To the Editor: A significant increase in the incidence of HLA-B8 and Dw3 has been reported in white patients with several autoimmune diseases, including juvenile-onset diabetes mellitus1 and Graves’ disease.23 Two possibilities to explain this phenomenon have been proposed.4 In the first, these two different organ-specific autoimmune diseases might be associated with the same allele of the same gene, and there might be a common initiating pathogenic event in these diseases; secondly, each of these diseases might be associated with a particular allele of different genes, both of which are in linkage disequilibrium with HLA-B8 and HLA-Dw3. Sasazuki et al.
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U2 - 10.1056/NEJM197803162981117
DO - 10.1056/NEJM197803162981117
M3 - Letter
C2 - 75503
AN - SCOPUS:0018270541
SN - 0028-4793
VL - 298
SP - 630
EP - 631
JO - New England Journal of Medicine
JF - New England Journal of Medicine
IS - 11
ER -
