HLA discrepancy between graft and host rather than that graft and first donor impact the second transplant outcome

Yoshinobu Maeda, Tomotaka Ugai, Eisei Kondo, Kazuhiro Ikegame, Makoto Murata, Naoyuki Uchida, Toshihiro Miyamoto, Satoshi Takahashi, Kazuteru Ohashi, Hirohisa Nakamae, Takahiro Fukuda, Makoto Onizuka, Tetsuya Eto, Shuichi Ota, Makoto Hirokawa, Tatsuo Ichinohe, Yoshiko Atsuta, Yoshinobu Kanda, Junya Kanda

研究成果: ジャーナルへの寄稿記事

抜粋

Second allogeneic hematopoietic stem cell transplantation is a curative treatment option for patients with hematologic malignancies. However, it is unclear whether HLA discrepancy between graft and first donor has an impact on the outcome of second transplantation. We retrospectively analyzed 646 patients receiving second transplantation after an initial HLA mismatched transplantation. With regard to graft-versus-host, the one-allele mismatch (1 mismatch) group (SHR, 1.88; 95%CI: 0.79-4.45; P=0.163) and more than one-allele mismatch group (≥ 2 mismatch) (SHR, 1.84; 95%CI, 0.75–4.51; P=0.182) had higher risks of grade III–IV acute graft-versus-host disease (GvHD) compared to the HLA-matched (0 mismatch) group. In contrast, no difference in risk of acute GvHD was found among the 0, 1, and ≥ 2 mismatch group with respect to graft-versus-first donor. With regard to graft-versus-host, the ≥ 2 mismatch group showed a significantly higher risk of treatment-related mortality (SHR, 1.90; 95%CI, 1.04–3.50; P=0.038) compared to the 0 mismatch group, while the risk of relapse was slightly lower in the ≥ 2 mismatch group (SHR, 068; 95%CI, 0.44–1.06; P=0.086). In contrast, with regard to graft-versus-first donor, there were no significant differences in treatment-related mortality or relapse among the three groups. These findings suggested that HLA discrepancy between graft and host induces transplant-related immunological responses in second transplantation leading to an increase in treatment-related mortality, in contrast, the biological effects of HLA discrepancy between graft and first donor on outcome may be negligible.

元の言語英語
ページ(範囲)1055-1061
ページ数7
ジャーナルHaematologica
104
発行部数5
DOI
出版物ステータス出版済み - 4 30 2019

    フィンガープリント

All Science Journal Classification (ASJC) codes

  • Hematology

これを引用

Maeda, Y., Ugai, T., Kondo, E., Ikegame, K., Murata, M., Uchida, N., ... Kanda, J. (2019). HLA discrepancy between graft and host rather than that graft and first donor impact the second transplant outcome. Haematologica, 104(5), 1055-1061. https://doi.org/10.3324/haematol.2018.204438