Homogeneous bioassays based on the manipulation of magnetic nanoparticles by rotating and alternating magnetic FieldsA comparison

Jan Henrik Dieckhoff, Takashi Yoshida, Keiji Enpuku, Meinhard Schilling, Frank Ludwig

研究成果: ジャーナルへの寄稿学術誌査読

25 被引用数 (Scopus)

抄録

The rotating magnetic field as a source of magnetic nanoparticle manipulation for the use in homogenous bioassays is presented and compared with the frequently used alternating magnetic field technique. For the investigation of the impact of the rotating and alternating field mode on the biomolecule detection, a fluxgate based measurement system has been used. This system detects the MNPs magnetization stray field and calculates the phase lag between the aligning field and the MNPs magnetization. By analyzing the phase lag, the analysis is not altered by changes in MNP concentration. The measured phase lag spectra show a significant difference between both magnetic field modes and agree well with simulations based on the Fokker-Planck equation. A modeling of binding experiments based on these simulations predicts a higher sensitivity for the rotating magnetic field manipulation.

本文言語英語
論文番号6332681
ページ(範囲)3792-3795
ページ数4
ジャーナルIEEE Transactions on Magnetics
48
11
DOI
出版ステータス出版済み - 2012

!!!All Science Journal Classification (ASJC) codes

  • 電子材料、光学材料、および磁性材料
  • 電子工学および電気工学

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