TY - JOUR
T1 - How to diagnose polysulphide poisoning from tissue samples
AU - Nagata, T.
AU - Kage, S.
AU - Kimura, K.
AU - Kudo, K.
AU - Imamura, T.
PY - 1994/11
Y1 - 1994/11
N2 - We carried out animal experiments to toxicologically verify polysulphide poisoning by analyzing tissue samples. A bathing agent containing calcium polysulphides was administered orally to rats, and then polysulphides and sulphide, the decomposed product of polysulphides, were analyzed by GC and GC/MS. The concentrations of polysulphides (μmol/ml or g) were found to be highest in blood (0.196), followed by the liver (0.051), the lungs (0.018) and kindneys (0.013), but were below the detection limit (0.005 μmol/g) in the other tissues tested. Sulphide was detected in all the tissue samples and was found to be highest in the blood (0.518 μmol/ml), this being 40 times higher than that required for fatal poisoning in the case of hydrogen sulphide. Polysulphide poisoning was considered to be confirmatively diagnosed by detecting and measuring polysuphides and supplementarily sulphide in body tissues, most pertinently in the blood. Two practical cases of suspected poisoning by polysulphides are briefly described.
AB - We carried out animal experiments to toxicologically verify polysulphide poisoning by analyzing tissue samples. A bathing agent containing calcium polysulphides was administered orally to rats, and then polysulphides and sulphide, the decomposed product of polysulphides, were analyzed by GC and GC/MS. The concentrations of polysulphides (μmol/ml or g) were found to be highest in blood (0.196), followed by the liver (0.051), the lungs (0.018) and kindneys (0.013), but were below the detection limit (0.005 μmol/g) in the other tissues tested. Sulphide was detected in all the tissue samples and was found to be highest in the blood (0.518 μmol/ml), this being 40 times higher than that required for fatal poisoning in the case of hydrogen sulphide. Polysulphide poisoning was considered to be confirmatively diagnosed by detecting and measuring polysuphides and supplementarily sulphide in body tissues, most pertinently in the blood. Two practical cases of suspected poisoning by polysulphides are briefly described.
UR - http://www.scopus.com/inward/record.url?scp=0028024633&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028024633&partnerID=8YFLogxK
U2 - 10.1007/BF01224772
DO - 10.1007/BF01224772
M3 - Article
C2 - 7947335
AN - SCOPUS:0028024633
VL - 106
SP - 288
EP - 290
JO - Zeitschrift fur Rechtsmedizin. Journal of legal medicine
JF - Zeitschrift fur Rechtsmedizin. Journal of legal medicine
SN - 0937-9827
IS - 6
ER -