Human colorectal CD24+ cancer stem cells are susceptible to epithelial-mesenchymal transition

Miho Okano, Masamitsu Konno, Yoshihiro Kano, Hirotoshi Kim, Koichi Kawamoto, Masahisa Ohkuma, Naotsugu Haraguchi, Takehiko Yokobori, Koshi Mimori, Hirofumi Yamamoto, Mitsugu Sekimoto, Yuichiro Doki, Masaki Mori, Hideshi Ishii

研究成果: Contribution to journalArticle査読

8 被引用数 (Scopus)

抄録

Conventional cancer chemotherapy preferentially destroys non-stem cancer cells within a tumor, and a subpopulation of cancer stem cells (CSCs) is more resistant and survives, leading to relapses and metastasis. Howeve, recent studies suggest that CD24 and susceptibility to epithelial-mesenchymal transition (EMT) can serve as markers of CSCs. We report that CD24+ cells are susceptible to induction of EMT, a phenotype important for cancer metastasis. We studied the responsiveness of CSC markers to TGF-β, an effective EMT inducer. The data on CD24 demonstrated that CD24+ cells are susceptible to EMT, a phenotype important for cancer metastasis in two colorectal cancer cell lines, the CaR-1 and CCK81. CD24+ cells expressed Notch 1 in response to exposure to TGF-β in culture and showed higher tumorigenic activity compared to controls. This evidence shows that CD24+ cells are susceptible to EMT induction and to cancer progression and is indicative of the candidacy of CD24 as a therapeutic target in CSC.

本文言語英語
ページ(範囲)575-580
ページ数6
ジャーナルInternational journal of oncology
45
2
DOI
出版ステータス出版済み - 8 2014

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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