Human lymphocytes are more susceptible to measles virus than granulocytes, which is attributable to the phenotypic differences of their membrane cofactor protein (CD46)

Mitsue Kurita, Yusuke Yanagi, Tomoko Hara, Shigeharu Nagasawa, Misako Matsumoto, Tsukasa Seya

研究成果: Contribution to journalArticle査読

5 被引用数 (Scopus)

抄録

Membrane cofactor protein (MCP, CD46) of the complement system is a measles virus (MV) receptor. Human lymphocytes express a heavily glycosylated (H) and a lightly glycosylated (L) form of MCP, which confers a two-band profile on SDS-PAGE the ratio of which is controlled genetically and organ-specifically. In contrast, granulocytes express a single heavily glycosylated form regardless of lymphocyte MCP phenotype. We investigated susceptibility to MV of granulocytes and lymphocytes from individuals with different lymphocyte MCP phenotypes. In any individual, granulocytes were > 10-fold less susceptible to MV than lymphocytes, and the lymphocytes with predominant H form were generally less susceptible to those with an increasing amount of L form. Thus, lymphocytes always exhibit high susceptibility to MV compared to granulocytes in all individuals. This finding may explain the lymphopenia and immunosuppression observed secondary to MV infection.

本文言語英語
ページ(範囲)91-95
ページ数5
ジャーナルImmunology Letters
48
2
DOI
出版ステータス出版済み - 12 1 1995

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

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