Human NAT10 is an ATP-dependent rna acetyltransferase responsible for N4-acetylcytidine formation in 18 S ribosomal RNA (rRNA)

Tsutomu Suzuki, Satoshi Ito, Sayuri Horikawa, Tateki Suzuki, Hiroki Kawauchi, Yoshikazu Tanaka, Takeo Suzuki

研究成果: Contribution to journalArticle査読

49 被引用数 (Scopus)

抄録

Human N-acetyltransferase 10 (NAT10) is known to be a lysine acetyltransferase that targets microtubules and histones and plays an important role in cell division. NAT10 is highly expressed in malignant tumors, and is also a promising target for therapies against laminopathies and premature aging. Here we report that NAT10 is an ATP-dependent RNA acetyltransferase responsible for formation of N4-acetylcytidine (ac4C) at position 1842 in the terminal helix of mammalian 18 S rRNA. RNAimediated knockdown of NAT10 resulted in growth retardation of human cells, and this was accompanied by high-level accumulation of the 30 S precursor of 18 S rRNA, suggesting that ac4C1842 formation catalyzed by NAT10 is involved in rRNA processing and ribosome biogenesis.

本文言語英語
ページ(範囲)35724-35730
ページ数7
ジャーナルJournal of Biological Chemistry
289
52
DOI
出版ステータス出版済み - 12 26 2014
外部発表はい

All Science Journal Classification (ASJC) codes

  • 生化学
  • 分子生物学
  • 細胞生物学

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「Human NAT10 is an ATP-dependent rna acetyltransferase responsible for N<sup>4</sup>-acetylcytidine formation in 18 S ribosomal RNA (rRNA)」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

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