Human placenta-derived cells have mesenchymal stem/progenitor cell potential

Yumi Fukuchi, Hideaki Nakajima, Daisuke Sugiyama, Imiko Hirose, Toshio Kitamura, Kohichiro Tsuji

    研究成果: Contribution to journalArticle査読

    481 被引用数 (Scopus)

    抄録

    Mesenchymal stem/progenitor cells (MSCs) are widely distributed in a variety of tissues in the adult human body (e.g., bone marrow [BM], kidney, lung, and liver). These cells are also present in the fetal environment (e.g., blood, liver, BM, and kidney). However, MSCs are a rare population in these tissues. Here we tried to identify cells with MSC-like potency in human placenta. We isolated adherent cells from trypsin-digested term placentas and established two clones by limiting dilution. We examined these cells for morphology, surface markers, gene expression patterns, and differentiation potential and found that they expressed several stem cell markers, hematopoietic/endothelial cell-related genes, and organ-specific genes, as determined by reverse transcription- polymerase chain reaction and fluorescence-activated cell sorter analysis. They also showed osteogenic and adipogenic differentiation potentials under appropriate conditions. We suggest that placenta-derived cells have multilineage differentiation potential similar to MSCs in terms of morphology, cell-surface antigen expression, and gene expression patterns. The placenta may prove to be a useful source of MSCs.

    本文言語英語
    ページ(範囲)649-658
    ページ数10
    ジャーナルSTEM CELLS
    22
    5
    DOI
    出版ステータス出版済み - 2004

    All Science Journal Classification (ASJC) codes

    • Molecular Medicine
    • Developmental Biology
    • Cell Biology

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