抄録
The two hemispheres of the human brain differ functionally and structurally. Despite over a century of research, the extent to which brain asymmetry is influenced by sex, handedness, age, and genetic factors is still controversial. Here we present the largest ever analysis of subcortical brain asymmetries, in a harmonized multi-site study using meta-analysis methods. Volumetric asymmetry of seven subcortical structures was assessed in 15,847 MRI scans from 52 datasets worldwide. There were sex differences in the asymmetry of the globus pallidus and putamen. Heritability estimates, derived from 1170 subjects belonging to 71 extended pedigrees, revealed that additive genetic factors influenced the asymmetry of these two structures and that of the hippocampus and thalamus. Handedness had no detectable effect on subcortical asymmetries, even in this unprecedented sample size, but the asymmetry of the putamen varied with age. Genetic drivers of asymmetry in the hippocampus, thalamus and basal ganglia may affect variability in human cognition, including susceptibility to psychiatric disorders.
本文言語 | 英語 |
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ページ(範囲) | 1-18 |
ページ数 | 18 |
ジャーナル | Brain Imaging and Behavior |
DOI | |
出版ステータス | 印刷中 - 10月 13 2016 |
!!!All Science Journal Classification (ASJC) codes
- 放射線学、核医学およびイメージング
- 神経学
- 認知神経科学
- 臨床神経学
- 細胞および分子神経科学
- 精神医学および精神衛生
- 行動神経科学