Hybrid chitosan membranes tested in sheep for guided tissue regeneration

P. P. Cortez, Y. Shirosaki, C. M. Botelho, M. J. Simões, F. Gartner, R. M.Gil Da Costa, Kanji Tsuru, S. Hayakawa, A. Osaka, M. A. Lopes, J. D. Santos, A. C. Maurício

研究成果: ジャーナルへの寄稿記事

3 引用 (Scopus)

抄録

Previous in vitro studies confirmed an improved cytocompatibility of chitosan-silicate hybrid membranes over chitosan membranes. The main goal of this study was to assess the in vivo histocompatibility of both membranes through subcutaneous implantations at different time periods, 1 week, 1, 2 and 3 months, using a sheep model. Chitosan membranes elicited an exuberant inflammatory response and were consequently rejected. The hybrid chitosan membranes were not rejected and the degree of inflammatory response decreased gradually until the third month of implantation. Histological evaluation also showed that these membranes can be resorbed in vivo. This study demonstrates that the incorporation of silicate into the chitosan solution improves its histocompatibility, indicating that the hybrid chitosan-silicate membranes are suitable candidates to be used in clinical applications.

元の言語英語
ページ(範囲)1265-1268
ページ数4
ジャーナルKey Engineering Materials
361-363 II
出版物ステータス出版済み - 1 22 2008

Fingerprint

Tissue regeneration
Chitosan
Membranes
Silicates

All Science Journal Classification (ASJC) codes

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

これを引用

Cortez, P. P., Shirosaki, Y., Botelho, C. M., Simões, M. J., Gartner, F., Da Costa, R. M. G., ... Maurício, A. C. (2008). Hybrid chitosan membranes tested in sheep for guided tissue regeneration. Key Engineering Materials, 361-363 II, 1265-1268.

Hybrid chitosan membranes tested in sheep for guided tissue regeneration. / Cortez, P. P.; Shirosaki, Y.; Botelho, C. M.; Simões, M. J.; Gartner, F.; Da Costa, R. M.Gil; Tsuru, Kanji; Hayakawa, S.; Osaka, A.; Lopes, M. A.; Santos, J. D.; Maurício, A. C.

:: Key Engineering Materials, 巻 361-363 II, 22.01.2008, p. 1265-1268.

研究成果: ジャーナルへの寄稿記事

Cortez, PP, Shirosaki, Y, Botelho, CM, Simões, MJ, Gartner, F, Da Costa, RMG, Tsuru, K, Hayakawa, S, Osaka, A, Lopes, MA, Santos, JD & Maurício, AC 2008, 'Hybrid chitosan membranes tested in sheep for guided tissue regeneration', Key Engineering Materials, 巻. 361-363 II, pp. 1265-1268.
Cortez PP, Shirosaki Y, Botelho CM, Simões MJ, Gartner F, Da Costa RMG その他. Hybrid chitosan membranes tested in sheep for guided tissue regeneration. Key Engineering Materials. 2008 1 22;361-363 II:1265-1268.
Cortez, P. P. ; Shirosaki, Y. ; Botelho, C. M. ; Simões, M. J. ; Gartner, F. ; Da Costa, R. M.Gil ; Tsuru, Kanji ; Hayakawa, S. ; Osaka, A. ; Lopes, M. A. ; Santos, J. D. ; Maurício, A. C. / Hybrid chitosan membranes tested in sheep for guided tissue regeneration. :: Key Engineering Materials. 2008 ; 巻 361-363 II. pp. 1265-1268.
@article{36a20a06a49345de8075de3e88349deb,
title = "Hybrid chitosan membranes tested in sheep for guided tissue regeneration",
abstract = "Previous in vitro studies confirmed an improved cytocompatibility of chitosan-silicate hybrid membranes over chitosan membranes. The main goal of this study was to assess the in vivo histocompatibility of both membranes through subcutaneous implantations at different time periods, 1 week, 1, 2 and 3 months, using a sheep model. Chitosan membranes elicited an exuberant inflammatory response and were consequently rejected. The hybrid chitosan membranes were not rejected and the degree of inflammatory response decreased gradually until the third month of implantation. Histological evaluation also showed that these membranes can be resorbed in vivo. This study demonstrates that the incorporation of silicate into the chitosan solution improves its histocompatibility, indicating that the hybrid chitosan-silicate membranes are suitable candidates to be used in clinical applications.",
author = "Cortez, {P. P.} and Y. Shirosaki and Botelho, {C. M.} and Sim{\~o}es, {M. J.} and F. Gartner and {Da Costa}, {R. M.Gil} and Kanji Tsuru and S. Hayakawa and A. Osaka and Lopes, {M. A.} and Santos, {J. D.} and Maur{\'i}cio, {A. C.}",
year = "2008",
month = "1",
day = "22",
language = "English",
volume = "361-363 II",
pages = "1265--1268",
journal = "Key Engineering Materials",
issn = "1013-9826",
publisher = "Trans Tech Publications",

}

TY - JOUR

T1 - Hybrid chitosan membranes tested in sheep for guided tissue regeneration

AU - Cortez, P. P.

AU - Shirosaki, Y.

AU - Botelho, C. M.

AU - Simões, M. J.

AU - Gartner, F.

AU - Da Costa, R. M.Gil

AU - Tsuru, Kanji

AU - Hayakawa, S.

AU - Osaka, A.

AU - Lopes, M. A.

AU - Santos, J. D.

AU - Maurício, A. C.

PY - 2008/1/22

Y1 - 2008/1/22

N2 - Previous in vitro studies confirmed an improved cytocompatibility of chitosan-silicate hybrid membranes over chitosan membranes. The main goal of this study was to assess the in vivo histocompatibility of both membranes through subcutaneous implantations at different time periods, 1 week, 1, 2 and 3 months, using a sheep model. Chitosan membranes elicited an exuberant inflammatory response and were consequently rejected. The hybrid chitosan membranes were not rejected and the degree of inflammatory response decreased gradually until the third month of implantation. Histological evaluation also showed that these membranes can be resorbed in vivo. This study demonstrates that the incorporation of silicate into the chitosan solution improves its histocompatibility, indicating that the hybrid chitosan-silicate membranes are suitable candidates to be used in clinical applications.

AB - Previous in vitro studies confirmed an improved cytocompatibility of chitosan-silicate hybrid membranes over chitosan membranes. The main goal of this study was to assess the in vivo histocompatibility of both membranes through subcutaneous implantations at different time periods, 1 week, 1, 2 and 3 months, using a sheep model. Chitosan membranes elicited an exuberant inflammatory response and were consequently rejected. The hybrid chitosan membranes were not rejected and the degree of inflammatory response decreased gradually until the third month of implantation. Histological evaluation also showed that these membranes can be resorbed in vivo. This study demonstrates that the incorporation of silicate into the chitosan solution improves its histocompatibility, indicating that the hybrid chitosan-silicate membranes are suitable candidates to be used in clinical applications.

UR - http://www.scopus.com/inward/record.url?scp=38149018476&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=38149018476&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:38149018476

VL - 361-363 II

SP - 1265

EP - 1268

JO - Key Engineering Materials

JF - Key Engineering Materials

SN - 1013-9826

ER -