Hybrid organoids consisting of extracellular matrix gel particles and hepatocytes for transplantation

Jingjia Ye, Nana Shirakigawa, Hiroyuki Ijima

研究成果: ジャーナルへの寄稿学術誌査読

6 被引用数 (Scopus)

抄録

Hepatocyte transplantation is a potential therapy for treating various liver diseases. However, oxygen shortage leading to loss of hepatocyte function becomes a limitation following hepatocyte transplantation. To overcome this problem, we developed a hybrid organoid, consisting of growth factor (GF)-immobilizable gel particles combined with hepatocytes. Benefits of the hybrid organoid were evaluated in three groups: (i) hybrid organoid consisting of cells and GF-immobilizable gel particles (HG-C); (ii) hybrid organoid consisting of cells and gel particles (G-C); and (iii) cells suspended in collagen (C-C). We found liver-specific functions of HG-C were maintained longer than in the other conditions during in vitro culture. Furthermore, after transplantation, HG-C was effective in maintaining viability of transplanted hepatocytes and promoting angiogenesis around the hepatocytes. In summary, transplantation of HG-C is a potential method for future liver tissue engineering.

本文言語英語
ページ(範囲)231-237
ページ数7
ジャーナルJournal of Bioscience and Bioengineering
120
2
DOI
出版ステータス出版済み - 8月 1 2015

!!!All Science Journal Classification (ASJC) codes

  • バイオテクノロジー
  • バイオエンジニアリング
  • 応用微生物学とバイオテクノロジー

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