Hydrogel formation between enantiomeric B-A-B-type block copolymers of polylactides (PLLA or PDLA: A) and polyoxyethylene (PEG: B); PEG-PLLA-PEG and PEG-PDLA-PEG

Takashi Mukose, Tomoko Fujiwara, Junko Nakano, Ikuo Taniguchi, Masatoshi Miyamoto, Yoshiharu Kimura, Iwao Teraoka, Chan Woo Lee

研究成果: Contribution to journalArticle査読

60 被引用数 (Scopus)

抄録

A mixed suspension of the enantiomeric B-A-B triblock copolymers, polyoxyethylene-block-poly(L-lactide)-block-polyoxyethylene (PEG-PLLA-PEG) and poly-oxyethylene-block-poly(D-lactide)-block-polyoxyethylene (PEG-PDLA-PEG), was found to induce reversible gel-to-sol transition depending on the polymer concentration and temperature. The storage and loss moduli of the gel formed at lower temperature were much higher than those of the gel prepared from the corresponding ABA-type triblock copolymers because of the higher polymer concentration in the former. Although the stereo-complexation of the PLLA and PDLA blocks occurred at higher temperature also in the B-A-B copolymers, it was not responsible for the gelation of the mixed suspension. The PEG chains, involved in the helix formation of the PLLA and PDLA, should form helices with opposite helical senses to aggregate and lead the gelation of the system.

本文言語英語
ページ(範囲)361-367
ページ数7
ジャーナルMacromolecular Bioscience
4
3
DOI
出版ステータス出版済み - 3 15 2004
外部発表はい

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Bioengineering
  • Biomaterials
  • Polymers and Plastics
  • Materials Chemistry

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