Hydrophobic cavity formed by oligopeptide for doxorubicin delivery based on dendritic poly(L-lysine)

Takuro Niidome, Hisayo Yamauchi, Kayo Takahashi, Kenshiro Naoyama, Kazuto Watanabe, Takeshi Mori, Yoshiki Katayama

研究成果: ジャーナルへの寄稿記事

8 引用 (Scopus)

抄録

To deliver anti-cancer drugs to tumors, a hydrophobic cavity was prepared in the dendritic molecule, dendritic poly(L-lysine) of sixth generation (KG6), which was used as a drug carrier. The dendritic molecule was modified with polyethylene glycol (PEG)-linked hydrophobic penta-phenylalanine or penta-Alanine. The hydrophobic cavity was formed between the KG6 and PEG chains. The penta-phenylalanine peptide was better in encapsulating doxorubicin (DOX) in the cavity compared with penta-Alanine. The loaded DOX was slowly released from the cavity, and it depended on pH. After intravenous injection, the DOX-loaded dendrimers accumulated in the tumor by the enhanced permeability and retention effect, and showed significant suppression of tumor growth without loss of body weight. These results indicate that hydrophobic oligopeptides can be used for forming a hydrophobic cavity in a dendritic molecule for delivery of anti-cancer drugs to tumor sites.

元の言語英語
ページ(範囲)1362-1373
ページ数12
ジャーナルJournal of Biomaterials Science, Polymer Edition
25
発行部数13
DOI
出版物ステータス出版済み - 9 2 2014

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Oligopeptides
Doxorubicin
Lysine
Tumors
Rubiaceae
Phenylalanine
Alanine
Polyethylene glycols
Molecules
Neoplasms
Dendrimers
Drug Carriers
Pharmaceutical Preparations
Peptides
Intravenous Injections
Permeability
Body Weight
Growth

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biomaterials
  • Bioengineering
  • Biomedical Engineering
  • Medicine(all)

これを引用

Hydrophobic cavity formed by oligopeptide for doxorubicin delivery based on dendritic poly(L-lysine). / Niidome, Takuro; Yamauchi, Hisayo; Takahashi, Kayo; Naoyama, Kenshiro; Watanabe, Kazuto; Mori, Takeshi; Katayama, Yoshiki.

:: Journal of Biomaterials Science, Polymer Edition, 巻 25, 番号 13, 02.09.2014, p. 1362-1373.

研究成果: ジャーナルへの寄稿記事

Niidome, Takuro ; Yamauchi, Hisayo ; Takahashi, Kayo ; Naoyama, Kenshiro ; Watanabe, Kazuto ; Mori, Takeshi ; Katayama, Yoshiki. / Hydrophobic cavity formed by oligopeptide for doxorubicin delivery based on dendritic poly(L-lysine). :: Journal of Biomaterials Science, Polymer Edition. 2014 ; 巻 25, 番号 13. pp. 1362-1373.
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AU - Mori, Takeshi

AU - Katayama, Yoshiki

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