Hydrophobic cavity formed by oligopeptide for doxorubicin delivery based on dendritic poly(L-lysine)

Takuro Niidome, Hisayo Yamauchi, Kayo Takahashi, Kenshiro Naoyama, Kazuto Watanabe, Takeshi Mori, Yoshiki Katayama

    研究成果: Contribution to journalArticle査読

    15 被引用数 (Scopus)

    抄録

    To deliver anti-cancer drugs to tumors, a hydrophobic cavity was prepared in the dendritic molecule, dendritic poly(L-lysine) of sixth generation (KG6), which was used as a drug carrier. The dendritic molecule was modified with polyethylene glycol (PEG)-linked hydrophobic penta-phenylalanine or penta-Alanine. The hydrophobic cavity was formed between the KG6 and PEG chains. The penta-phenylalanine peptide was better in encapsulating doxorubicin (DOX) in the cavity compared with penta-Alanine. The loaded DOX was slowly released from the cavity, and it depended on pH. After intravenous injection, the DOX-loaded dendrimers accumulated in the tumor by the enhanced permeability and retention effect, and showed significant suppression of tumor growth without loss of body weight. These results indicate that hydrophobic oligopeptides can be used for forming a hydrophobic cavity in a dendritic molecule for delivery of anti-cancer drugs to tumor sites.

    本文言語英語
    ページ(範囲)1362-1373
    ページ数12
    ジャーナルJournal of Biomaterials Science, Polymer Edition
    25
    13
    DOI
    出版ステータス出版済み - 9 2 2014

    All Science Journal Classification (ASJC) codes

    • 生物理学
    • バイオエンジニアリング
    • 生体材料
    • 生体医工学

    フィンガープリント

    「Hydrophobic cavity formed by oligopeptide for doxorubicin delivery based on dendritic poly(L-lysine)」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

    引用スタイル