Hydrosilane Reduction of Nitriles to Primary Amines by Cobalt-Isocyanide Catalysts

Atsushi Sanagawa, Hideo Nagashima

研究成果: ジャーナルへの寄稿学術誌査読

16 被引用数 (Scopus)

抄録

Reduction of nitriles to silylated primary amines was achieved by combination of 1,1,3,3-tetramethyldisiloxane (TMDS) as the hydrosilane and a catalytic amount of Co(OPIV) 2 (PIV = CO t Bu) associated with isocyanide ligands. The resulting silylated amines were subjected to acid hydrolysis or treatment with acid chlorides to give the corresponding primary amines or imides in good yields. One-pot synthesis of primary amides to primary amines with hydrosilanes was also achieved by iron-cobalt dual catalyst systems.

本文言語英語
ページ(範囲)287-291
ページ数5
ジャーナルOrganic letters
21
1
DOI
出版ステータス出版済み - 1月 4 2019

!!!All Science Journal Classification (ASJC) codes

  • 生化学
  • 物理化学および理論化学
  • 有機化学

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