抄録
Reduction of nitriles to silylated primary amines was achieved by combination of 1,1,3,3-tetramethyldisiloxane (TMDS) as the hydrosilane and a catalytic amount of Co(OPIV) 2 (PIV = CO t Bu) associated with isocyanide ligands. The resulting silylated amines were subjected to acid hydrolysis or treatment with acid chlorides to give the corresponding primary amines or imides in good yields. One-pot synthesis of primary amides to primary amines with hydrosilanes was also achieved by iron-cobalt dual catalyst systems.
| 元の言語 | 英語 |
|---|---|
| ページ（範囲） | 287-291 |
| ページ数 | 5 |
| ジャーナル | Organic Letters |
| 巻 | 21 |
| 発行部数 | 1 |
| DOI | |
| 出版物ステータス | 出版済み - 1 4 2019 |
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All Science Journal Classification (ASJC) codes
- Biochemistry
- Physical and Theoretical Chemistry
- Organic Chemistry
これを引用
Hydrosilane Reduction of Nitriles to Primary Amines by Cobalt-Isocyanide Catalysts. / Sanagawa, Atsushi; Nagashima, Hideo.
：: Organic Letters, 巻 21, 番号 1, 04.01.2019, p. 287-291.研究成果: ジャーナルへの寄稿 › 記事
}
TY - JOUR
T1 - Hydrosilane Reduction of Nitriles to Primary Amines by Cobalt-Isocyanide Catalysts
AU - Sanagawa, Atsushi
AU - Nagashima, Hideo
PY - 2019/1/4
Y1 - 2019/1/4
N2 - Reduction of nitriles to silylated primary amines was achieved by combination of 1,1,3,3-tetramethyldisiloxane (TMDS) as the hydrosilane and a catalytic amount of Co(OPIV) 2 (PIV = CO t Bu) associated with isocyanide ligands. The resulting silylated amines were subjected to acid hydrolysis or treatment with acid chlorides to give the corresponding primary amines or imides in good yields. One-pot synthesis of primary amides to primary amines with hydrosilanes was also achieved by iron-cobalt dual catalyst systems.
AB - Reduction of nitriles to silylated primary amines was achieved by combination of 1,1,3,3-tetramethyldisiloxane (TMDS) as the hydrosilane and a catalytic amount of Co(OPIV) 2 (PIV = CO t Bu) associated with isocyanide ligands. The resulting silylated amines were subjected to acid hydrolysis or treatment with acid chlorides to give the corresponding primary amines or imides in good yields. One-pot synthesis of primary amides to primary amines with hydrosilanes was also achieved by iron-cobalt dual catalyst systems.
UR - http://www.scopus.com/inward/record.url?scp=85059576579&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85059576579&partnerID=8YFLogxK
U2 - 10.1021/acs.orglett.8b03736
DO - 10.1021/acs.orglett.8b03736
M3 - Article
VL - 21
SP - 287
EP - 291
JO - Organic Letters
JF - Organic Letters
SN - 1523-7060
IS - 1
ER -