Hydroxy-carbonate apatite: Synthesis, blood compatibility and adsorption of specific pathogenic proteins

Satoshi Hayakawa, Yuko Kusudo, Shinji Takemoto, Kanji Tsuru, Akiyoshi Osaka, Seisuke Takashima

研究成果: Contribution to conferencePaper査読

5 被引用数 (Scopus)

抄録

Hydroxy-carbonate apatite (CAp) compositions containing carbonate ions from 0 to 10.9 wt% were synthesized by a wet chemical method. Infrared analysis revealed that carbonate ions were substituted both PO43- and OH- sites. The introduction of CO32- ion into the hydroxyapatite lattice led to an increase in specific surface area and surface charge density. Blood clotting properties were not affected by the contact with CAp samples. The adsorption behavior of proteins was investigated by contacting CAp with model saline containing bovine serum albumin (BSA) and β2-microglobulin (β2-MG). The selectivity against β2-MG increased with increase in the amount of carbonate ions. As surface charge density increased with increase in the amount of carbonate ions, surface charge density played an important role in selective adsorption of β2-MG, but not a sole factor.

本文言語英語
ページ111-119
ページ数9
出版ステータス出版済み - 12 1 2003
イベントBioceramics: Materials and Applications IV, Proceedings - Nashville, TN, 米国
継続期間: 4 27 20034 30 2003

その他

その他Bioceramics: Materials and Applications IV, Proceedings
国/地域米国
CityNashville, TN
Period4/27/034/30/03

All Science Journal Classification (ASJC) codes

  • セラミックおよび複合材料
  • 材料化学

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