Hydroxylation mediates chromatin demethylation

研究成果: Contribution to journalReview article査読

19 被引用数 (Scopus)

抄録

Methylation of DNA and histones in chromatin has been implicated in numerous biological processes. For many years, methylation has been recognized as static and stable modification, as compared with other covalent modifications of chromatin. Recently, however, several mechanisms have been demonstrated to be involved in demethylation of chromatin, suggesting that chromatin methylation is more dynamically regulated. One chemical reaction that mediates demethylation of both DNA and histones is hydroxylation, catalysed by Fe(II) and α-ketoglutarate (KG)-dependent hydroxylase/dioxygenase. Given that methylation of chromatin is an important epigenetic mark involved in fundamental biological processes such as cell fate determination, understanding how chromatin methylation is dynamically regulated has implications for human diseases and regenerative medicine.

本文言語英語
ページ(範囲)229-246
ページ数18
ジャーナルJournal of biochemistry
151
3
DOI
出版ステータス出版済み - 3 2012

All Science Journal Classification (ASJC) codes

  • 生化学
  • 分子生物学

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