Hyperglycemia promotes microinflammation as evaluated by C-reactive protein in the very elderly

Masayo Fukuhara, Kiyoshi Matsumura, Masanori Wakisaka, Yutaka Takata, Kazuo Sonoki, Kiyoshi Fujisawa, Toshihiro Ansai, Sumio Akifusa, Koji Fujii, Mitsuo Iida, Tadamichi Takehara

研究成果: ジャーナルへの寄稿記事

20 引用 (Scopus)

抄録

Objective: C-reactive protein (CRP) is not only an acute phase reactant but also a sensitive marker of sub-clinical inflammation associated with atherosclerosis. The aim of the present study was to determine whether glycemic control or blood pressure influences the vascular microinflammation as evaluated by CRP levels in the very elderly. Methods: The study group consisted of 195 residents aged 85 years. The subjects were divided into three groups according to their CRP levels; a low (<1 mg/L), an average (1 to 3 mg/L), and a high (3 to 10 mg/L) CRP group. Hemoglobin A1c (HbA1c) levels were used as an index of glycemic control. Results: The HbA1c level showed a significant positive correlation with the CRP level (r=0.289, p<0.0001). In contrast, systolic and diastolic blood pressures failed to correlate with the CRP level. The Hb1c was significantly greater in the high CRP group compared to the average and the low CRP groups (6.01±0.29%, 5.57±0.09% and 5.42±0.05%, respectively). Furthermore, the HbA1c adjusted by sex, body mass index, systolic blood pressure, serum triglyceride and current smoking status was significantly higher in the high CRP group than in the average and the low CRP groups. Multiple regression analysis also revealed that the HbA1c level was significantly and independently associated with the CRP level. Conclusions: These results suggest that tight good glycemic control, even in very elderly subjects, may be able to reduce the systemic inflammation that contributes to leads to atherosclerosis.

元の言語英語
ページ(範囲)207-212
ページ数6
ジャーナルInternal Medicine
46
発行部数5
DOI
出版物ステータス出版済み - 3 1 2007

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Hyperglycemia
C-Reactive Protein
Blood Pressure
Hemoglobins
Atherosclerosis
Inflammation
Glycemic Index
Acute-Phase Proteins
Blood Vessels
Triglycerides
Body Mass Index
Biomarkers
Smoking
Regression Analysis

All Science Journal Classification (ASJC) codes

  • Internal Medicine

これを引用

Fukuhara, M., Matsumura, K., Wakisaka, M., Takata, Y., Sonoki, K., Fujisawa, K., ... Takehara, T. (2007). Hyperglycemia promotes microinflammation as evaluated by C-reactive protein in the very elderly. Internal Medicine, 46(5), 207-212. https://doi.org/10.2169/internalmedicine.46.1868

Hyperglycemia promotes microinflammation as evaluated by C-reactive protein in the very elderly. / Fukuhara, Masayo; Matsumura, Kiyoshi; Wakisaka, Masanori; Takata, Yutaka; Sonoki, Kazuo; Fujisawa, Kiyoshi; Ansai, Toshihiro; Akifusa, Sumio; Fujii, Koji; Iida, Mitsuo; Takehara, Tadamichi.

:: Internal Medicine, 巻 46, 番号 5, 01.03.2007, p. 207-212.

研究成果: ジャーナルへの寄稿記事

Fukuhara, M, Matsumura, K, Wakisaka, M, Takata, Y, Sonoki, K, Fujisawa, K, Ansai, T, Akifusa, S, Fujii, K, Iida, M & Takehara, T 2007, 'Hyperglycemia promotes microinflammation as evaluated by C-reactive protein in the very elderly', Internal Medicine, 巻. 46, 番号 5, pp. 207-212. https://doi.org/10.2169/internalmedicine.46.1868
Fukuhara M, Matsumura K, Wakisaka M, Takata Y, Sonoki K, Fujisawa K その他. Hyperglycemia promotes microinflammation as evaluated by C-reactive protein in the very elderly. Internal Medicine. 2007 3 1;46(5):207-212. https://doi.org/10.2169/internalmedicine.46.1868
Fukuhara, Masayo ; Matsumura, Kiyoshi ; Wakisaka, Masanori ; Takata, Yutaka ; Sonoki, Kazuo ; Fujisawa, Kiyoshi ; Ansai, Toshihiro ; Akifusa, Sumio ; Fujii, Koji ; Iida, Mitsuo ; Takehara, Tadamichi. / Hyperglycemia promotes microinflammation as evaluated by C-reactive protein in the very elderly. :: Internal Medicine. 2007 ; 巻 46, 番号 5. pp. 207-212.
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abstract = "Objective: C-reactive protein (CRP) is not only an acute phase reactant but also a sensitive marker of sub-clinical inflammation associated with atherosclerosis. The aim of the present study was to determine whether glycemic control or blood pressure influences the vascular microinflammation as evaluated by CRP levels in the very elderly. Methods: The study group consisted of 195 residents aged 85 years. The subjects were divided into three groups according to their CRP levels; a low (<1 mg/L), an average (1 to 3 mg/L), and a high (3 to 10 mg/L) CRP group. Hemoglobin A1c (HbA1c) levels were used as an index of glycemic control. Results: The HbA1c level showed a significant positive correlation with the CRP level (r=0.289, p<0.0001). In contrast, systolic and diastolic blood pressures failed to correlate with the CRP level. The Hb1c was significantly greater in the high CRP group compared to the average and the low CRP groups (6.01±0.29{\%}, 5.57±0.09{\%} and 5.42±0.05{\%}, respectively). Furthermore, the HbA1c adjusted by sex, body mass index, systolic blood pressure, serum triglyceride and current smoking status was significantly higher in the high CRP group than in the average and the low CRP groups. Multiple regression analysis also revealed that the HbA1c level was significantly and independently associated with the CRP level. Conclusions: These results suggest that tight good glycemic control, even in very elderly subjects, may be able to reduce the systemic inflammation that contributes to leads to atherosclerosis.",
author = "Masayo Fukuhara and Kiyoshi Matsumura and Masanori Wakisaka and Yutaka Takata and Kazuo Sonoki and Kiyoshi Fujisawa and Toshihiro Ansai and Sumio Akifusa and Koji Fujii and Mitsuo Iida and Tadamichi Takehara",
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AU - Fukuhara, Masayo

AU - Matsumura, Kiyoshi

AU - Wakisaka, Masanori

AU - Takata, Yutaka

AU - Sonoki, Kazuo

AU - Fujisawa, Kiyoshi

AU - Ansai, Toshihiro

AU - Akifusa, Sumio

AU - Fujii, Koji

AU - Iida, Mitsuo

AU - Takehara, Tadamichi

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N2 - Objective: C-reactive protein (CRP) is not only an acute phase reactant but also a sensitive marker of sub-clinical inflammation associated with atherosclerosis. The aim of the present study was to determine whether glycemic control or blood pressure influences the vascular microinflammation as evaluated by CRP levels in the very elderly. Methods: The study group consisted of 195 residents aged 85 years. The subjects were divided into three groups according to their CRP levels; a low (<1 mg/L), an average (1 to 3 mg/L), and a high (3 to 10 mg/L) CRP group. Hemoglobin A1c (HbA1c) levels were used as an index of glycemic control. Results: The HbA1c level showed a significant positive correlation with the CRP level (r=0.289, p<0.0001). In contrast, systolic and diastolic blood pressures failed to correlate with the CRP level. The Hb1c was significantly greater in the high CRP group compared to the average and the low CRP groups (6.01±0.29%, 5.57±0.09% and 5.42±0.05%, respectively). Furthermore, the HbA1c adjusted by sex, body mass index, systolic blood pressure, serum triglyceride and current smoking status was significantly higher in the high CRP group than in the average and the low CRP groups. Multiple regression analysis also revealed that the HbA1c level was significantly and independently associated with the CRP level. Conclusions: These results suggest that tight good glycemic control, even in very elderly subjects, may be able to reduce the systemic inflammation that contributes to leads to atherosclerosis.

AB - Objective: C-reactive protein (CRP) is not only an acute phase reactant but also a sensitive marker of sub-clinical inflammation associated with atherosclerosis. The aim of the present study was to determine whether glycemic control or blood pressure influences the vascular microinflammation as evaluated by CRP levels in the very elderly. Methods: The study group consisted of 195 residents aged 85 years. The subjects were divided into three groups according to their CRP levels; a low (<1 mg/L), an average (1 to 3 mg/L), and a high (3 to 10 mg/L) CRP group. Hemoglobin A1c (HbA1c) levels were used as an index of glycemic control. Results: The HbA1c level showed a significant positive correlation with the CRP level (r=0.289, p<0.0001). In contrast, systolic and diastolic blood pressures failed to correlate with the CRP level. The Hb1c was significantly greater in the high CRP group compared to the average and the low CRP groups (6.01±0.29%, 5.57±0.09% and 5.42±0.05%, respectively). Furthermore, the HbA1c adjusted by sex, body mass index, systolic blood pressure, serum triglyceride and current smoking status was significantly higher in the high CRP group than in the average and the low CRP groups. Multiple regression analysis also revealed that the HbA1c level was significantly and independently associated with the CRP level. Conclusions: These results suggest that tight good glycemic control, even in very elderly subjects, may be able to reduce the systemic inflammation that contributes to leads to atherosclerosis.

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