Hypersensitivity to pentylenetetrazol-induced convulsion in mice lacking the PLC-related inactive protein-1

Taku Yamaguchi, Takashi Kubota, Takashi Kanematsu, Keiichi Nakayama, Masato Hirata, Tsuneyuki Yamamoto

研究成果: Contribution to journalArticle査読

4 被引用数 (Scopus)

抄録

In the present study, we investigated the effects of pentylenetetrazol (PTZ), a chemical convulsant that interacts with the GABA A receptor, in mice lacking the phospholipase C (PLC)-related inactive protein-1 (PRIP-1). PRIP-1 knockout mice did not develop spontaneous behavioral seizure. PRIP-1 knockout mice had markedly shorter latencies until the first clonic convulsion (CL) and tonic extensor (TE) following PTZ administration and increased incidence of convulsion compared to those in wild-type mice. Furthermore, the mortality rate by PTZ in mice lacking the PRIP-1 was also significantly increased in comparison with that in wild-type mice. These findings suggested that mice lacking the PRIP-1 were hypersensitive to PTZ-induced convulsion, and PRIP-1 might play roles in suppressing excessive excitability via interactions with the GABA A receptor.

本文言語英語
ページ(範囲)237-240
ページ数4
ジャーナルBrain Research
1025
1-2
DOI
出版ステータス出版済み - 10 29 2004

All Science Journal Classification (ASJC) codes

  • 神経科学(全般)
  • 分子生物学
  • 臨床神経学
  • 発生生物学

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