Objectives: Pneumonia is one of the major causes of death in the elderly. The aim of the present study was to investigate factors related to the development of community-acquired pneumonia (CAP) as well as to evaluate the preventive effect of pneumococcal vaccination on CAP in the elderly in sub-group analyses. Methods: We performed a hospital-based case-control study. Cases were 70 patients who were newly diagnosed as having CAP while 146 controls were outpatients with other diseases (not pneumonia). All participants were 65 years and older. Results: Even after controlling for age, sex and hospital, hypoalbuminemia(< 3.5 g/dl) (adjusted OR = 4.15, 95%CI = 1.76-9.80) showed an increased risk of CAP, whereas activities of daily living (ADL) was inversely associated with a risk of CAP (self-supported vs. impaired: adjusted OR = 0.45, 95%CI = 0.22-0.93). In sub-group analyses, pneumococcal vaccination showed a decreased risk among the elderly with hypoalbuminemia (Crude OR = 0.22, 95%CI = 0.06-0.86). Even after controlling for age, sex, and hospital, pneumococcal vaccination showed an odds ratio lower than the unity although it failed to show statistical significance. Conclusions: Hypoalbuminemia and impaired ability to perform ADL may increase the risk of CAP in the elderly, whereas pneumococcal vaccination may prevent CAP among the elderly with hypoalbuminemia.
|ジャーナル||International Medical Journal|
|出版ステータス||出版済み - 2 2020|
All Science Journal Classification (ASJC) codes