Hypoglycemic effect of surfactant-coated insulin solubilized in a novel solid-in-oil-in-water (S/O/W) emulsion

Eiichi Toorisaka, Hiroshige Ono, Kazuhiko Arimori, Noriho Kamiya, Masahiro Goto

研究成果: ジャーナルへの寄稿学術誌査読

88 被引用数 (Scopus)

抄録

A novel solid-in-oil-in-water (S/O/W) emulsion for oral administration of insulin has been developed using surfactant-coated insulin. The S/O/W emulsion prepared by a shirasu porous glass (SPG) membrane provided a sharp size distribution and was stable. Leakage of insulin from the S/O/W emulsions was not observed for several days. The S/O/W emulsion showed the hypoglycemic activity for a long period after oral administration to rats.

本文言語英語
ページ(範囲)271-274
ページ数4
ジャーナルInternational Journal of Pharmaceutics
252
1-2
DOI
出版ステータス出版済み - 2月 18 2003

!!!All Science Journal Classification (ASJC) codes

  • 薬科学

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