Hypoglycemic effect of surfactant-coated insulin solubilized in a novel solid-in-oil-in-water (S/O/W) emulsion

Eiichi Toorisaka; Hiroshige Ono; Kazuhiko Arimori; Noriho Kamiya; Masahiro Goto

doi:10.1016/S0378-5173(02)00674-9

Hypoglycemic effect of surfactant-coated insulin solubilized in a novel solid-in-oil-in-water (S/O/W) emulsion

Eiichi Toorisaka, Hiroshige Ono, Kazuhiko Arimori, Noriho Kamiya, Masahiro Goto

応用化学

研究成果: ジャーナルへの寄稿 › 学術誌 › 査読

88 被引用数 (Scopus)

抄録

A novel solid-in-oil-in-water (S/O/W) emulsion for oral administration of insulin has been developed using surfactant-coated insulin. The S/O/W emulsion prepared by a shirasu porous glass (SPG) membrane provided a sharp size distribution and was stable. Leakage of insulin from the S/O/W emulsions was not observed for several days. The S/O/W emulsion showed the hypoglycemic activity for a long period after oral administration to rats.

本文言語	英語
ページ（範囲）	271-274
ページ数	4
ジャーナル	International Journal of Pharmaceutics
巻	252
号	1-2
DOI	https://doi.org/10.1016/S0378-5173(02)00674-9
出版ステータス	出版済み - 2月 18 2003

!!!All Science Journal Classification (ASJC) codes

薬科学

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10.1016/S0378-5173(02)00674-9

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T1 - Hypoglycemic effect of surfactant-coated insulin solubilized in a novel solid-in-oil-in-water (S/O/W) emulsion

AU - Toorisaka, Eiichi

AU - Ono, Hiroshige

AU - Arimori, Kazuhiko

AU - Kamiya, Noriho

AU - Goto, Masahiro

PY - 2003/2/18

Y1 - 2003/2/18

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AB - A novel solid-in-oil-in-water (S/O/W) emulsion for oral administration of insulin has been developed using surfactant-coated insulin. The S/O/W emulsion prepared by a shirasu porous glass (SPG) membrane provided a sharp size distribution and was stable. Leakage of insulin from the S/O/W emulsions was not observed for several days. The S/O/W emulsion showed the hypoglycemic activity for a long period after oral administration to rats.

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AN - SCOPUS:0037452443

VL - 252

SP - 271

EP - 274

JO - International Journal of Pharmaceutics

JF - International Journal of Pharmaceutics

SN - 0378-5173

IS - 1-2

ER -

Hypoglycemic effect of surfactant-coated insulin solubilized in a novel solid-in-oil-in-water (S/O/W) emulsion

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!!!All Science Journal Classification (ASJC) codes

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