Hypothalamic microdialysis of mazindol causes anorexia with increase in synaptic serotonin in rats

Nobuaki Shimizu, Sachiko Take, Tetsuro Hori, Yutaka Oomura

研究成果: Contribution to journalArticle査読

11 被引用数 (Scopus)

抄録

Brain microdialysis was used to determine if lateral hypothalamic serotonin (5-HT) is involved in the mazindol-induced anorexia in rats. Direct application of mazindol through a microdialysis membrane both significantly increased the 5-HT levels in the lateral hypothalamus and suppressed food intake by fasted rats. The increase in 5-HT concentration was dose related and the concentration of mazindol for half-maximal response was 4.6 μM. Pretreatment with methysergide, a potent 5-HT receptor-blocking agent, significantly antagonized the mazindol-induced anorexia. These results suggest that the anorectic action of mazindol might be mediated, at least in part, through serotonergic mechanisms in the hypothalamus.

本文言語英語
ページ(範囲)131-134
ページ数4
ジャーナルPhysiology and Behavior
49
1
DOI
出版ステータス出版済み - 1 1991

All Science Journal Classification (ASJC) codes

  • 実験心理学および認知心理学
  • 行動神経科学

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