Hypothermia induced by central injection of sucralose potentially occurs via monoaminergic pathways in the hypothalamus of chicks

Hatem M. Eltahan, Linh T.N. Nguyen, Guofeng Han, Hui Yang, Mohamed N. Ali, Khairy A. Amber, Mitsuhiro Furuse, Vishwajit S. Chowdhury

研究成果: ジャーナルへの寄稿学術誌査読

3 被引用数 (Scopus)


Oral administration of sucralose has been reported to stimulate food intake through inducing hypothalamic neuropeptide Y (NPY) in mice and fruit flies. However, the underlying mechanisms of action of sucralose in hypothermia and NPY and monoamine regulation remain unknown. The aim of the present study was to investigate central effects of sucralose on body temperature, NPY, and monoamine regulation, as well as its peripheral effects, in chicks. In Experiment 1, 5-day-old chicks were centrally injected with 1 μmol of sucralose, other sweeteners (erythritol and glucose), or saline. In Experiment 2, chicks were centrally injected with 0.2, 0.4, and 1.6 μmol of sucralose or saline. In Experiment 3, chicks were centrally injected with 0.8 μmol of sucralose or saline, with a co-injection of 100 μg fusaric acid (FA), an inhibitor of dopamine-β-hydroxylase, to examine the role dopamine in sucralose induced hypothermia. In Experiment 4, 7–16-day-old chicks were orally administered with 75, 150, and 300 mg/2 ml distilled water or sucralose, daily. We observed that the central injection of sucralose, but not other sweeteners, decreased body temperature (P < .05) in chicks; however, the oral injection did not influence body temperature, food intake, and body weight gain. Central sucralose administration decreased dopamine and serotonin and stimulated dopamine turnover rate in the hypothalamus significantly (P < .05). Notably, sucralose co-injection with FA impeded sucralose-induced hypothermia. Sucralose decreases body temperature potentially via central monoaminergic pathways in the hypothalamus.

ジャーナルComparative Biochemistry and Physiology -Part A : Molecular and Integrative Physiology
出版ステータス出版済み - 10月 2020

!!!All Science Journal Classification (ASJC) codes

  • 生化学
  • 生理学
  • 水圏科学
  • 動物科学および動物学
  • 分子生物学


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