IκB kinase epsilon expression in adipocytes is upregulated by interaction with macrophages

Yohei Sanada, Takahiro Kumoto, Haruna Suehiro, Takafumi Yamamoto, Fusanori Nishimura, Norihisa Kato, Noriyuki Yanaka

研究成果: Contribution to journalArticle査読

5 被引用数 (Scopus)


Macrophage infiltration in the adipose tissue, and the interaction with adipocytes, is well documented to be involved in fat inflammation and obesity-associated complications. In this study, we isolated IκB kinase ε (IKKε) as a key adipocyte factor that is potentially affected by interaction with macrophages in adipose tissue in vivo. We showed that IKKε mRNA expression levels in white adipose tissue were increased in both genetic and diet-induced obese mouse. Furthermore, IKKε mRNA expression was decreased by the administration of vitamin B6, an anti-inflammatory vitamin, and that IKKε expression levels in adipose tissue were closely correlated with the numbers of infiltrating macrophages. In a co-culture system, we showed that IKKaε expression in adipocytes was upregulated by interaction with activated macrophages. This study provides novel insight into IKKε, which is involved in adipose tissue inflammation during the development of obesity.

ジャーナルBioscience, Biotechnology and Biochemistry
出版ステータス出版済み - 2014

All Science Journal Classification (ASJC) codes

  • バイオテクノロジー
  • 分析化学
  • 生化学
  • 応用微生物学とバイオテクノロジー
  • 分子生物学
  • 有機化学


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