Identification of a five-pass transmembrane protein family localizing in the Golgi apparatus and the ER

Abbas Shakoori, Gourou Fujii, Shin Ichiro Yoshimura, Masashi Kitamura, Kazuhisa Nakayama, Takashi Ito, Hiroshi Ohno, Nobuhiro Nakamura

研究成果: ジャーナルへの寄稿記事

22 引用 (Scopus)

抄録

A family of five-pass transmembrane proteins (FinGERs) were identified from the protein sequence database. The family includes yeast Yip1p, Yip4p, Yip5p, and Yif1p, and also their plant, insects, nematode, and mammalian homologues, suggesting their conserved function in a broad range of species. Eight family members were found in human. Multiple sequence alignment revealed three regions conserved among all family members. All of the human family members were expressed widely in various tissues. The human proteins were localized in and around the Golgi apparatus and may also be in the ER to some extent. The Golgi apparatus was fragmented by overexpression of the five of the family members. Some of the members were found to interact by yeast two-hybrid analysis, suggesting the formation of a complex. These results suggest that FinGERs function in maintenance of the Golgi structure and/or transport between the ER and the Golgi apparatus.

元の言語英語
ページ(範囲)850-857
ページ数8
ジャーナルBiochemical and Biophysical Research Communications
312
発行部数3
DOI
出版物ステータス出版済み - 12 19 2003

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Golgi Apparatus
Yeast
Proteins
Yeasts
Tissue
Protein Databases
Sequence Alignment
Insects
Maintenance

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

これを引用

Identification of a five-pass transmembrane protein family localizing in the Golgi apparatus and the ER. / Shakoori, Abbas; Fujii, Gourou; Yoshimura, Shin Ichiro; Kitamura, Masashi; Nakayama, Kazuhisa; Ito, Takashi; Ohno, Hiroshi; Nakamura, Nobuhiro.

:: Biochemical and Biophysical Research Communications, 巻 312, 番号 3, 19.12.2003, p. 850-857.

研究成果: ジャーナルへの寄稿記事

Shakoori, Abbas ; Fujii, Gourou ; Yoshimura, Shin Ichiro ; Kitamura, Masashi ; Nakayama, Kazuhisa ; Ito, Takashi ; Ohno, Hiroshi ; Nakamura, Nobuhiro. / Identification of a five-pass transmembrane protein family localizing in the Golgi apparatus and the ER. :: Biochemical and Biophysical Research Communications. 2003 ; 巻 312, 番号 3. pp. 850-857.
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AU - Shakoori, Abbas

AU - Fujii, Gourou

AU - Yoshimura, Shin Ichiro

AU - Kitamura, Masashi

AU - Nakayama, Kazuhisa

AU - Ito, Takashi

AU - Ohno, Hiroshi

AU - Nakamura, Nobuhiro

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