Identification of a five-pass transmembrane protein family localizing in the Golgi apparatus and the ER

Abbas Shakoori, Gourou Fujii, Shin Ichiro Yoshimura, Masashi Kitamura, Kazuhisa Nakayama, Takashi Ito, Hiroshi Ohno, Nobuhiro Nakamura

研究成果: ジャーナルへの寄稿学術誌査読

27 被引用数 (Scopus)

抄録

A family of five-pass transmembrane proteins (FinGERs) were identified from the protein sequence database. The family includes yeast Yip1p, Yip4p, Yip5p, and Yif1p, and also their plant, insects, nematode, and mammalian homologues, suggesting their conserved function in a broad range of species. Eight family members were found in human. Multiple sequence alignment revealed three regions conserved among all family members. All of the human family members were expressed widely in various tissues. The human proteins were localized in and around the Golgi apparatus and may also be in the ER to some extent. The Golgi apparatus was fragmented by overexpression of the five of the family members. Some of the members were found to interact by yeast two-hybrid analysis, suggesting the formation of a complex. These results suggest that FinGERs function in maintenance of the Golgi structure and/or transport between the ER and the Golgi apparatus.

本文言語英語
ページ(範囲)850-857
ページ数8
ジャーナルBiochemical and Biophysical Research Communications
312
3
DOI
出版ステータス出版済み - 12月 19 2003
外部発表はい

!!!All Science Journal Classification (ASJC) codes

  • 生物理学
  • 生化学
  • 分子生物学
  • 細胞生物学

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