Identification of a frameshift mutation resulting in premature termination and loss of cell wall anchoring of the PAc antigen of Streptococcus mutans GS-5

Y. Murakami, Y. Nakano, Yoshihisa Yamashita, T. Koga

研究成果: ジャーナルへの寄稿記事

31 引用 (Scopus)

抄録

Most strains of Streptococcus mutans possess a 190-kDa protein antigen (PAc) on their cell surfaces, while strain GS-5 produces extracellularly a 155-kDa PAc protein. The pac gene of strain GS-5 consists of 3,477 bp and codes for a protein of 1,158 amino acids. One insertion of an adenine into the 3,469th, 3,470th, or 3,471st position from the start codon results in a frameshift mutation at codon 1157 with subsequent termination after 3 additional codons.

元の言語英語
ページ(範囲)794-797
ページ数4
ジャーナルInfection and Immunity
65
発行部数2
出版物ステータス出版済み - 1997

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Frameshift Mutation
Streptococcus mutans
Cell Wall
Antigens
Codon
Proteins
Initiator Codon
Adenine
Amino Acids
Genes
mutacin GS-5

All Science Journal Classification (ASJC) codes

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases

これを引用

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T1 - Identification of a frameshift mutation resulting in premature termination and loss of cell wall anchoring of the PAc antigen of Streptococcus mutans GS-5

AU - Murakami, Y.

AU - Nakano, Y.

AU - Yamashita, Yoshihisa

AU - Koga, T.

PY - 1997

Y1 - 1997

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AB - Most strains of Streptococcus mutans possess a 190-kDa protein antigen (PAc) on their cell surfaces, while strain GS-5 produces extracellularly a 155-kDa PAc protein. The pac gene of strain GS-5 consists of 3,477 bp and codes for a protein of 1,158 amino acids. One insertion of an adenine into the 3,469th, 3,470th, or 3,471st position from the start codon results in a frameshift mutation at codon 1157 with subsequent termination after 3 additional codons.

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