Identification of a Methylated Tea Catechin as an Inhibitor of Degranulation in Human Basophilic KU812 Cells

Hirofumi Tachibana, Yousuke Sunada, Toshio Miyase, Mitsuaki Sano, Mari Maeda-Yamamoto, Koji Yamada

研究成果: ジャーナルへの寄稿学術誌査読

61 被引用数 (Scopus)

抄録

We examined the constituents of tea that had an inhibitory effect on the degranulation process in the human basophilic cell line, KU812. Among the constituents purified from a extract of ‘Benihomare’ oolong tea by column chromatography, a methylated (-)-epigallocatechin gallate ((-)-epigallocatechin 3-O-(3-O-methyl) gallate) was found to inhibit the degranulation of KU812 cells that had been stimulated with calcium ionophore A23187. The inhibitory effect of this methylated (-)-epigallocatechin gallate on degranulation was greater than that of (-)-epigallocatechin gallate. This result indicates that methylation of (-)-epigallocatechin gallate may be an effective modification for the catechin to inhibit degranulation from human basophils.

本文言語英語
ページ(範囲)452-454
ページ数3
ジャーナルBioscience, Biotechnology and Biochemistry
64
2
DOI
出版ステータス出版済み - 1月 1 2000

!!!All Science Journal Classification (ASJC) codes

  • バイオテクノロジー
  • 分析化学
  • 生化学
  • 応用微生物学とバイオテクノロジー
  • 分子生物学
  • 有機化学

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