Identification of fasting-induced genes in the rat hypothalamus: Relationship with neuroprotection

Takuya Chiba, Satoshi Fujita, Haruaki Kubota, Daisuke Inoue, Aya Mizuno, Toshimitsu Komatsu, Haruyoshi Yamaza, Yoshikazu Higami, Isao Shimokawa

研究成果: ジャーナルへの寄稿記事

7 引用 (Scopus)

抄録

During food shortage, organisms activate defense mechanisms to maximize their chance of survival. At least in part, these responses are triggered by changes in hormonal status and neural status during starvation. The hypothalamus is organized as a collection of distinct autonomously active nuclei and is considered to play crucial roles in these survival responses. To isolate factors involved in these pathways, we carried out suppression subtractive hybridization analyses using complementary DNAs (cDNA) from the hypothalami of fasted and fed rats. We identified four genes, namely ubiquitin-conjugating enzyme E2D 3 (UBE2D3), cAMP-dependent protein kinase C beta subunit (PKCβ), excitatory amino acid carrier 1 (EAAC1), and ferritin heavy polypeptide 1 (Fth1), that were upregulated after a 48-h fast compared to the fed status. According to previous reports, these genes have been implicated in protection against neuronal cell death under various neurodegenerative stresses, such as hypoxia-ischemia and oxidative stress. Thus, the increased expressions of the genes identified in the present study may have protective effects against neural damage that could otherwise result in cell death.

元の言語英語
ページ(範囲)216-226
ページ数11
ジャーナルAnnals of the New York Academy of Sciences
1119
発行部数1
DOI
出版物ステータス出版済み - 1 1 2007
外部発表Yes

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Hypothalamus
Rats
Fasting
Cell Death
Genes
Ubiquitin-Conjugating Enzymes
Cell death
Protein Kinase C beta
Excitatory Amino Acids
Defense Mechanisms
Ferritins
Starvation
Cyclic AMP-Dependent Protein Kinases
Oxidative Stress
Oxidative stress
Ischemia
Complementary DNA
Gene Expression
Food
Peptides

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

これを引用

Identification of fasting-induced genes in the rat hypothalamus : Relationship with neuroprotection. / Chiba, Takuya; Fujita, Satoshi; Kubota, Haruaki; Inoue, Daisuke; Mizuno, Aya; Komatsu, Toshimitsu; Yamaza, Haruyoshi; Higami, Yoshikazu; Shimokawa, Isao.

:: Annals of the New York Academy of Sciences, 巻 1119, 番号 1, 01.01.2007, p. 216-226.

研究成果: ジャーナルへの寄稿記事

Chiba, T, Fujita, S, Kubota, H, Inoue, D, Mizuno, A, Komatsu, T, Yamaza, H, Higami, Y & Shimokawa, I 2007, 'Identification of fasting-induced genes in the rat hypothalamus: Relationship with neuroprotection', Annals of the New York Academy of Sciences, 巻. 1119, 番号 1, pp. 216-226. https://doi.org/10.1196/annals.1404.013
Chiba, Takuya ; Fujita, Satoshi ; Kubota, Haruaki ; Inoue, Daisuke ; Mizuno, Aya ; Komatsu, Toshimitsu ; Yamaza, Haruyoshi ; Higami, Yoshikazu ; Shimokawa, Isao. / Identification of fasting-induced genes in the rat hypothalamus : Relationship with neuroprotection. :: Annals of the New York Academy of Sciences. 2007 ; 巻 1119, 番号 1. pp. 216-226.
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