Identification of novel genes with prognostic value in childhood leukemia using cDNA microarray and quantitative RT-PCR

Hiroyoshi Hattori, Akinobu Matsukaki, Aiko Suminoe, Yuhki Koga, Kosuke Tashiro, Toshiro Hara

研究成果: Contribution to journalArticle査読

7 被引用数 (Scopus)

抄録

The aim of this study was to identify genes distinctively expressed or suppressed in childhood leukemia with different prognoses, using cDNA microarray and quantitative reverse transcription-polymerase chain reaction (RT-PCR). The expression levels of the selected genes by cDNA microarray were quantified in primary leukemic blasts from 44 patients (acute lymphoblastic leukemia, 28; acute myelogenous leukemia (AML), 13; transient myeloproliferative disorder, 3). The expression levels of CDKN2C, CRADD, and IGFBP-2 genes were significantly associated with the event-free survival of the patients in AML. The present results suggest that a combination of cDNA microarray and quantitative RT-PCR may be useful to identify novel genes with prognostic value in childhood AML.

本文言語英語
ページ(範囲)115-127
ページ数13
ジャーナルPediatric Hematology and Oncology
23
2
DOI
出版ステータス出版済み - 3 2006

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology

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