TY - JOUR
T1 - Identification of SMEK2 as a candidate gene for regulation of responsiveness to dietary cholesterol in rats
AU - Asahina, Makoto
AU - Haruyama, Waka
AU - Ichida, Yasuhiro
AU - Sakamoto, Mai
AU - Sato, Masao
AU - Imaizumi, Katsumi
PY - 2009
Y1 - 2009
N2 - We have previously mapped a diet-induced hypercholesterolemia locus (Dihc2) to chromosome 14 in the F2 generation cross of high-responsive exogenous hypercholesterolemia rats and low-responsive BN rats. To identify a causal gene within this locus, we constructed intervalspecific congenic lines and carried out expression and sequencing analyses. Here we narrowed Dihc2 to a region including 33 genes and predicted transcripts and identified RGD1309450∥edicted, a homologous gene of SMEK2, as a strong candidate for responsiveness to dietary cholesterol. Our finding provides new insights into the pathway underlying the individual responsiveness to dietary cholesterol in vivo.
AB - We have previously mapped a diet-induced hypercholesterolemia locus (Dihc2) to chromosome 14 in the F2 generation cross of high-responsive exogenous hypercholesterolemia rats and low-responsive BN rats. To identify a causal gene within this locus, we constructed intervalspecific congenic lines and carried out expression and sequencing analyses. Here we narrowed Dihc2 to a region including 33 genes and predicted transcripts and identified RGD1309450∥edicted, a homologous gene of SMEK2, as a strong candidate for responsiveness to dietary cholesterol. Our finding provides new insights into the pathway underlying the individual responsiveness to dietary cholesterol in vivo.
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U2 - 10.1194/jlr.M800135-JLR200
DO - 10.1194/jlr.M800135-JLR200
M3 - Article
C2 - 18753676
AN - SCOPUS:63449121979
SN - 0022-2275
VL - 50
SP - 41
EP - 46
JO - Journal of Lipid Research
JF - Journal of Lipid Research
IS - 1
ER -