Identification of sur2 mutation affecting the lifespan of fission yeast

Tatsuhiro Kurauchi, Kotaro Matsui, Takafumi Shimasaki, Hokuto Ohtsuka, Satoshi Tsubouchi, Kunio Ihara, Motohiro Tani, Hirofumi Aiba

研究成果: ジャーナルへの寄稿学術誌査読

1 被引用数 (Scopus)

抄録

Yeast is a suitable model system to analyze the mechanism of lifespan. In this study, to identify novel factors involved in chronological lifespan, we isolated a mutant with a long chronological lifespan and found a missense mutation in the sur2+ gene, which encodes a homolog of Saccharomyces cerevisiae sphingolipid C4-hydroxylase in fission yeast. Characterization of the mutant revealed that loss of sur2 function resulted in an extended chronological lifespan. The effect of caloric restriction, a well-known signal for extending lifespan, is thought to be dependent on the sur2+ gene.

本文言語英語
論文番号fnab070
ジャーナルFEMS microbiology letters
368
12
DOI
出版ステータス出版済み - 7月 1 2021

!!!All Science Journal Classification (ASJC) codes

  • 微生物学
  • 分子生物学
  • 遺伝学

フィンガープリント

「Identification of sur2 mutation affecting the lifespan of fission yeast」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル